Reactome | PIK3R1 D560Y [plasma membrane]

PIK3R1 D560Y [plasma membrane]

Stable Identifier

R-HSA-2399421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PIK3R1 Asp560Tyr

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560Y [plasma membrane] (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560Y [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560Y [plasma membrane] (Homo sapiens)

General

The substitution of aspartic acid residue with tyrosine at position 560 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 D560Y mutant (Jaiswal et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19962665	Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation Yue, P, Kaminker, JS, Kan, Z, Modrusan, Z, Dbouk, HA, Kenski, DM, Stinson, J, Waring, P, Janakiraman, V, Stern, HM, Wang, W, Jaiswal, BS, Lorenzo, M, Peters, BA, Seshagiri, S, Chaudhuri, S, Eby, M, Bowman, KK, Wu, J, Kljavin, NM, Dela Vega, T, Backer, JM, de Sauvage, FJ, Li, H	Cancer Cell	2009

External Reference Information

External Reference

UniProt:P27986 PIK3R1

Gene Names

PIK3R1, GRB1

Chain

initiator methionine:, chain:2-724

Reference Genes

BioGPS Gene:5295 PIK3R1

COSMIC (genes):PIK3R1 PIK3R1

CTD Gene:5295 PIK3R1

dbSNP Gene:5295 PIK3R1

ENSEMBL:ENSG00000145675 PIK3R1

HGNC:8979 PIK3R1

KEGG:hsa:5295 PIK3R1

Monarch:5295 PIK3R1

NCBI Gene:5295 PIK3R1

OMIM:171833 PIK3R1

UCSC:P27986 PIK3R1

Reference Transcript

Participates

as a member of

PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

PIK3R1 [plasma membrane]

PIK3R1 [cytosol]

K63polyUb-PIK3R1 [cytosol]

PIK3R1 R574T [plasma membrane]

PIK3R1 R574I [plasma membrane]

PIK3R1 D560H [plasma membrane]

PIK3R1 N564K [plasma membrane]

PIK3R1 K459del [plasma membrane]

PIK3R1 N564D [plasma membrane]

PIK3R1 R574_T576del [plasma membrane]

PIK3R1 H450_E451del [plasma membrane]

PIK3R1 Y463_L466del [plasma membrane]

PIK3R1 K379E [plasma membrane]

PIK3R1 G376R [plasma membrane]

p-Y-PIK3R1 [cytosol]

Modified Residues

Name

L-aspartic acid 560 replaced with L-tyrosine

Coordinate

560

PsiMod

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

L-tyrosine residue

A protein modification that effectively converts a source amino acid residue to L-tyrosine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme

Cross References

RefSeq

XP_016865074.1, NP_852556.2, NP_001229395.1, XP_005248599.1, NP_852664.1, NP_852665.1

Guide to Pharmacology - Targets

2503

OpenTargets

ENSG00000145675

ENSEMBL

ENST00000517643, ENST00000523872, ENST00000521657, ENSP00000323512, ENSP00000513319, ENSP00000513316, ENST00000336483, ENST00000320694, ENSP00000338554, ENSP00000513325, ENSG00000145675, ENSP00000430098, ENST00000697467, ENSP00000513333, ENST00000697458, ENST00000521381, ENST00000697461, ENSP00000429277, ENSP00000428056

ZINC - Substances

P85A_HUMAN

ZINC - Biogenic

P85A_HUMAN

ZINC target

P27986

PRO

P27986

PDB

8GUB, 8V8J, 2V1Y, 8AM0, 8SBJ, 5SXC, 8H37, 8ILS, 8H36, 5XGJ, 7CIO, 8W9B, 2IUH, 5SXF, 3HHM, 7MYO, 7PG5, 8TSA, 5SW8, 5M6U, 4OVV, 8TS9, 5SWP, 5SWG, 8DD4, 5SX9, 7TZ7, 1A0N, 5SXB, 1AZG, 3I5R, 1H9O, 8V8H, 5SXI, 5XGI, 5ITD, 7RNS, 8W9A, 8TS7, 8SBC, 4YKN, 5SWO, 5SWR, 4L2Y, 5GJI, 8TSB, 5UKJ, 5AUL, 4L23, 3I5S, 8DD8, 8V8U, 8ILR, 8V8I, 7MYN, 5XGH, 5SXE, 2IUG, 5SXK, 2IUI, 5VLR, 8TS8, 8TU6, 4WAF, 4JPS, 4L1B, 6PYR, 8TSC, 8DCP, 5SX8, 6NCT, 7LQ1, 5UL1, 8TDU, 8ILV, 5SXA, 1PKS, 7PG6, 5SXD, 1PKT, 5SXJ, 8DCX, 8V8V, 4OVU, 7LM2, 4A55, 1PHT, 1PIC, 4ZOP, 5UK8, 8TGD, 5SWT, 3HIZ, 8TSD, 5UBT, 5FI4, 1PBW, 2RD0, 6PYU

ZINC - Metabolites

P85A_HUMAN

COSMIC

COSV57123942

GeneCards

PIK3R1

HPA

ENSG00000145675-PIK3R1

Pharos - Targets

P27986

Orphanet

PIK3R1

ZINC - Predictions - Purchasable

P85A_HUMAN

HMDB Protein

HMDBP03978

Interactors (78)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA [cytosol] (R-HSA-74787) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA Q546K [cytosol] (R-HSA-1500705)	0.967	64
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.951	21
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.94	16
UniProt:P21860 ERBB3			0.921	41
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.921	13
UniProt:P10747 CD28	3	p-Y191-CD28 [plasma membrane] (R-HSA-388756) CD28 [plasma membrane] (R-HSA-167632) CD28 [cytosol] (R-HSA-167628)	0.903	10
UniProt:O00329 PIK3CD	2	PIK3CD [plasma membrane] (R-HSA-392274) PIK3CD [cytosol] (R-HSA-1806204)	0.888	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.863	6
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.84	6
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.816	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.81	7
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.803	6
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.796	33
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.794	10
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.779	7
UniProt:P06213 INSR	6	INSR(28-758) [plasma membrane] (R-HSA-74668) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(763-1382) [plasma membrane] (R-HSA-74669) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719)	0.767	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.759	12
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417_D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.749	19
UniProt:P62999	6	RAC1 [ficolin-1-rich granule membrane] (R-CFA-6804802-2) RAC1 [secretory granule membrane] (R-CFA-6804770-2) GGC-PalmC-RAC1 [plasma membrane] (R-CFA-2316446-2) RAC1 [endoplasmic reticulum membrane] (R-CFA-5672076-2) RAC1 [cytosol] (R-CFA-442615-2) RAC1 [plasma membrane] (R-CFA-351141-2)	0.717	5
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.688	3
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.688	3
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.659	6
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.644	6
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.643	3
UniProt:P16410 CTLA4	2	CTLA4 [plasma membrane] (R-HSA-179764) p-Y201,Y218-CTLA4 [plasma membrane] (R-HSA-388754)	0.643	3
UniProt:P30874 SSTR2	1	SSTR2 [plasma membrane] (R-HSA-374757)	0.639	5
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.624	4
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.623	4
UniProt:Q9Y6W8 ICOS	1	ICOS [plasma membrane] (R-HSA-9845023)	0.623	5
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.623	6
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.611	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.597	3
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.597	3
UniProt:Q99152 VP3			0.591	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:P43405 SYK	6	SYK [cytosol] (R-HSA-58268) p-Y348-SYK [cytosol] (R-HSA-437953) p-6Y-SYK [cytosol] (R-HSA-1861712) SYK [plasma membrane] (R-HSA-139844) p-Y-SYK [plasma membrane] (R-HSA-429432) p-Y-SYK [cytosol] (R-HSA-9705732)	0.581	5
UniProt:P41970 ELK3			0.573	2
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.571	2
UniProt:P29376 LTK	2	LTK [plasma membrane] (R-HSA-9842564) p-6Y-LTK [plasma membrane] (R-HSA-9842578)	0.569	3
UniProt:Q13111 CAF1A			0.564	2
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.564	2
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.564	2
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.556	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.553	7
UniProt:Q13746 Q13746			0.544	3
UniProt:O43493 TGOLN2	8	TGOLN2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869127) TGOLN2 [plasma membrane] (R-HSA-8864458) TGOLN2 [Golgi membrane] (R-HSA-434342) TGOLN2 [cytoplasmic vesicle membrane] (R-HSA-429818) TGOLN2 [trans-Golgi network membrane] (R-HSA-6811008) TGOLN2 [transport vesicle] (R-HSA-6811011) p-TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956886) TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956702)	0.536	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.536	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.536	2
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.536	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	2
UniProt:P09564 CD7			0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:Q86VI4-3 LAPTM4B			0.524	2
UniProt:Q8BM65-4 NYAP2			0.524	3
UniProt:Q8IY22 CMIP			0.524	2
UniProt:Q6PFX7 NYAP1			0.524	4
UniProt:P48025 Syk	8	p-Syk [cytosol] (R-MMU-9676057) phospho-p-Y-SYK [cytosol] (R-MMU-9705732) phospho-p-Y-SYK [plasma membrane] (R-MMU-429432) Syk [cytosol] (R-MMU-442293) p-Y348,Y352,Y525,Y526-Syk [cytosol] (R-MMU-5621123) phospho-p-6Y-SYK [cytosol] (R-MMU-1861712) phospho-p-Y348-SYK [cytosol] (R-MMU-437953) SYK [cytosol] (R-MMU-58268)	0.524	2
UniProt:O15455 TLR3	6	TLR3 [endosome membrane] (R-HSA-2000341) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730)	0.524	2
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.519	3
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.519	2
UniProt:Q9Y2I1 NISCH	1	NISCH [cytosol] (R-HSA-9691384)	0.508	2
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.488	2
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.483	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.483	7
UniProt:P21145 MAL			0.463	3
UniProt:O00329-2 PIK3CD			0.463	2
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.463	3
UniProt:P30875	1	Sstr2 [plasma membrane] (R-MMU-374757)	0.462	2
UniProt:P06127 CD5			0.462	2
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.462	3
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.462	4
UniProt:O14733 MAP2K7	4	p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353) MAP2K7 [cytosol] (R-HSA-450276) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401)	0.462	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802)	0.462	5
UniProt:P29350 PTPN6	5	PTPN6 [cytosol] (R-HSA-197938) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641)	0.462	2
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.462	2
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.462	3
UniProt:O43561 LAT	3	p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.462	4

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