Reactome | PIK3R1 D560H [plasma membrane]

PIK3R1 D560H [plasma membrane]

Stable Identifier

R-HSA-2399432

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PIK3R1 Asp560His

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)

General

The substitution of aspartic acid residue with histidine at the position 560 in the iSH2 domain of PIK3R1 is expected to relieve the inhibitory effect on the PI3K catalytic subunit, PIK3CA, and enable constitutive activity of PI3K complex that contains PIK3R1 D560H mutant, as shown for PIK3R1 D560Y mutant (Jaiswal et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19962665	Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation Yue, P, Kaminker, JS, Kan, Z, Modrusan, Z, Dbouk, HA, Kenski, DM, Stinson, J, Waring, P, Janakiraman, V, Stern, HM, Wang, W, Jaiswal, BS, Lorenzo, M, Peters, BA, Seshagiri, S, Chaudhuri, S, Eby, M, Bowman, KK, Wu, J, Kljavin, NM, Dela Vega, T, Backer, JM, de Sauvage, FJ, Li, H	Cancer Cell	2009

External Reference Information

External Reference

UniProt:P27986 PIK3R1

Gene Names

PIK3R1, GRB1

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:5295 PIK3R1

COSMIC (genes):PIK3R1 PIK3R1

CTD Gene:5295 PIK3R1

dbSNP Gene:5295 PIK3R1

ENSEMBL:ENSG00000145675.15 PIK3R1

HGNC:8979 PIK3R1

KEGG Gene (Homo sapiens):5295 PIK3R1

Monarch:5295 PIK3R1

NCBI Gene:5295 PIK3R1

OMIM:171833 PIK3R1

UCSC:P27986 PIK3R1

Reference Transcript

Other Identifiers

0000770592

0001190184

0004610204

0005050156

11733017_a_at

11733018_s_at

11733019_a_at

11739539_a_at

11739540_a_at

11739541_a_at

11748670_a_at

11754631_x_at

1269_at

16985518

212239_PM_at

212239_at

212240_PM_s_at

212240_s_at

212249_PM_at

212249_at

2813091

2813092

2813101

2813102

2813103

2813125

2813127

2813132

2813134

2813135

2813137

2813139

2813140

2813142

2813143

2813145

2813146

2813148

2813150

2813152

2813153

2813154

2813155

2813156

2813157

2813158

2813159

35373_at

44015_at

5295

55623_at

73148_at

73150_g_at

77475_at

8105778

A_14_P105607

A_24_P29401

GE58013

GE85962

GE88834

GO:0001678

GO:0001784

GO:0001953

GO:0002376

GO:0002687

GO:0005068

GO:0005158

GO:0005159

GO:0005168

GO:0005515

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005794

GO:0005801

GO:0005829

GO:0005886

GO:0005911

GO:0005942

GO:0005943

GO:0006351

GO:0006355

GO:0006366

GO:0006468

GO:0006606

GO:0006629

GO:0006886

GO:0006913

GO:0006955

GO:0007010

GO:0007155

GO:0007162

GO:0007165

GO:0008286

GO:0008625

GO:0008630

GO:0010592

GO:0012501

GO:0014065

GO:0015031

GO:0016020

GO:0019903

GO:0023052

GO:0030154

GO:0030183

GO:0030217

GO:0030316

GO:0032760

GO:0032869

GO:0032991

GO:0033120

GO:0034330

GO:0034446

GO:0034644

GO:0034976

GO:0035014

GO:0036211

GO:0036312

GO:0042307

GO:0043066

GO:0043125

GO:0043226

GO:0043548

GO:0043551

GO:0043559

GO:0043560

GO:0045671

GO:0045944

GO:0046326

GO:0046626

GO:0046854

GO:0046935

GO:0046982

GO:0048009

GO:0048471

GO:0048856

GO:0048870

GO:0050821

GO:0051491

GO:0051492

GO:0051497

GO:0055085

GO:0060090

GO:0060396

GO:0072659

GO:0097529

GO:0098772

GO:0120183

GO:1900103

GO:1903076

GO:1903078

GO:1990578

HMNXSV003040338

Hs.6241.0.S1_3p_a_at

Hs.6241.0.S2_3p_at

Hs.6241.0.S3_3p_at

ILMN_1689057

ILMN_1691433

ILMN_1760303

ILMN_2289433

ILMN_2398235

M61906_at

PH_hs_0021977

TC05000291.hg

Participates

as a candidate of

PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-PIK3R1 [cytosol]

PIK3R1 G376R [plasma membrane]

PIK3R1 K379E [plasma membrane]

PIK3R1 Y463_L466del [plasma membrane]

PIK3R1 H450_E451del [plasma membrane]

PIK3R1 R574_T576del [plasma membrane]

PIK3R1 D560Y [plasma membrane]

PIK3R1 N564D [plasma membrane]

PIK3R1 K459del [plasma membrane]

PIK3R1 N564K [plasma membrane]

PIK3R1 R574I [plasma membrane]

PIK3R1 R574T [plasma membrane]

K63polyUb-PIK3R1 [cytosol]

PIK3R1 [cytosol]

PIK3R1 [plasma membrane]

Modified Residues

Name

L-aspartic acid 560 replaced with L-histidine

Coordinate

560

PsiMod

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

L-histidine residue [MOD:00018]

A protein modification that effectively converts a source amino acid residue to an L-histidine.

Disease

Name	Identifier	Synonyms
pharynx cancer	DOID:0060119
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_852664.1, NP_852665.1, XP_016865074.1, NP_852556.2, NP_001229395.1, XP_005248599.1

ZINC - World Drugs

P85A_HUMAN

Guide to Pharmacology - Targets

2503

OpenTargets

ENSG00000145675

ZINC - Substances

P85A_HUMAN

ZINC - Biogenic

P85A_HUMAN

ZINC target

P27986

PRO

P27986

PDB

5XGI, 5SWR, 5XGJ, 5SWT, 4L1B, 7CIO, 1PHT, 4L2Y, 1PBW, 2IUH, 5SW8, 7MYO, 7RNS, 7MYN, 5UBT, 2IUG, 5SX9, 5SX8, 4A55, 5M6U, 5SXI, 5SWG, 1PKS, 1PKT, 1A0N, 5SXJ, 2RD0, 5VLR, 5ITD, 5SXK, 4WAF, 5SXA, 5SXB, 4OVU, 5SWO, 4OVV, 5UKJ, 3HIZ, 4ZOP, 5SWP, 5SXC, 5SXD, 5UL1, 5XGH, 2IUI, 5SXE, 5SXF, 1AZG, 4JPS, 3I5S, 5UK8, 6PYU, 4L23, 3I5R, 6PYR, 3HHM, 4YKN, 5GJI, 7LM2, 5AUL, 6NCT, 5FI4, 1H9O, 7LQ1, 2V1Y, 1PIC

ZINC - Metabolites

P85A_HUMAN

COSMIC

COSV57127598

GeneCards

P27986

HPA

ENSG00000145675-PIK3R1

Ensembl

ENST00000521657, ENSP00000430098, ENSP00000338554, ENST00000523872, ENST00000521381, ENST00000320694, ENST00000336483, ENSP00000323512, ENSG00000145675, ENSP00000429277, ENSP00000428056

Pharos - Targets

P27986

ZINC - Predictions - Purchasable

P85A_HUMAN

Orphanet

22044

HMDB Protein

HMDBP03978

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.963	26
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.947	20
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.94	16
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.921	13
UniProt:P21860 ERBB3			0.921	41
UniProt:P10747 CD28	3	p-Y191-CD28 [plasma membrane] (R-HSA-388756) CD28 [plasma membrane] (R-HSA-167632) CD28 [cytosol] (R-HSA-167628)	0.903	10
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.863	6
UniProt:O00329 PIK3CD	2	PIK3CD [cytosol] (R-HSA-1806204) PIK3CD [plasma membrane] (R-HSA-392274)	0.851	8
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.816	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.81	7
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.803	6
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.796	33
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.794	10
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y416-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.779	7
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.767	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.759	12
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.749	19
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.731	4
UniProt:P62999 RAC1			0.717	5
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.688	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.688	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.675	3
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.659	6
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.644	6
UniProt:P16410 CTLA4	2	p-Y165,Y182-CTLA4 [plasma membrane] (R-HSA-388754) CTLA4 [plasma membrane] (R-HSA-179764)	0.643	3
UniProt:P30874 SSTR2	1	SSTR2 [plasma membrane] (R-HSA-374757)	0.639	5
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.624	4
UniProt:Q9Y6W8 ICOS			0.623	5
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.623	6
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.611	3
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.597	3
UniProt:Q99152 VP3			0.591	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.581	5
UniProt:P41970 ELK3			0.573	2
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.571	2
UniProt:Q13111 CAF1A			0.564	2
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) p-Y-Irs1 [cytosol] (R-RNO-112362) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.564	2
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.564	2
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.556	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.553	7
UniProt:Q13746 Q13746			0.544	3
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.536	2
UniProt:O43493 TGOLN2	8	TGOLN2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869127) TGOLN2 [plasma membrane] (R-HSA-8864458) TGOLN2 [Golgi membrane] (R-HSA-434342) TGOLN2 [cytoplasmic vesicle membrane] (R-HSA-429818) TGOLN2 [trans-Golgi network membrane] (R-HSA-6811008) TGOLN2 [transport vesicle] (R-HSA-6811011) p-TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956886) TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956702)	0.536	2
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.536	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.536	2
UniProt:P29376 LTK			0.527	2
UniProt:Q86VI4-3 LAPTM4B			0.524	2
UniProt:Q8BM65-4 NYAP2			0.524	3
UniProt:Q8IY22 CMIP			0.524	2
UniProt:Q6PFX7 NYAP1			0.524	4
UniProt:P48025 Syk	8	p-Syk [cytosol] (R-MMU-9676057) phospho-p-Y-SYK [cytosol] (R-MMU-9705732) phospho-p-Y-SYK [plasma membrane] (R-MMU-429432) Syk [cytosol] (R-MMU-442293) p-Y348,Y352,Y525,Y526-Syk [cytosol] (R-MMU-5621123) phospho-p-6Y-SYK [cytosol] (R-MMU-1861712) phospho-p-Y348-SYK [cytosol] (R-MMU-437953) SYK [cytosol] (R-MMU-58268)	0.524	2
UniProt:O15455 TLR3	6	TLR3 [endosome membrane] (R-HSA-2000341) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730)	0.524	2
UniProt:P21709 EPHA1	2	EPHA1 [plasma membrane] (R-HSA-211415) p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336)	0.519	2
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.519	3
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.488	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.483	7
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.463	3
UniProt:P21145 MAL			0.463	3
UniProt:O00329-2 PIK3CD			0.463	2
UniProt:P30875	1	Sstr2 [plasma membrane] (R-MMU-374757)	0.462	2
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.462	3
UniProt:P06127 CD5			0.462	2
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.462	3
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.462	5
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.462	4
UniProt:O43561 LAT	3	p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.462	4
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.462	2
UniProt:O14733 MAP2K7	4	MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.462	3
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA [nucleoplasm] (R-HSA-4656929) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.462	2

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