Reactome | PIK3R1 D560H [plasma membrane]

PIK3R1 D560H [plasma membrane]

Stable Identifier

R-HSA-2399432

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PIK3R1 Asp560His

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
        
        PIK3R1 mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
        
        PIK3R1 D560H [plasma membrane] (Homo sapiens)

General

The substitution of aspartic acid residue with histidine at the position 560 in the iSH2 domain of PIK3R1 is expected to relieve the inhibitory effect on the PI3K catalytic subunit, PIK3CA, and enable constitutive activity of PI3K complex that contains PIK3R1 D560H mutant, as shown for PIK3R1 D560Y mutant (Jaiswal et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19962665	Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation Jaiswal, BS, Janakiraman, V, Kljavin, NM, Chaudhuri, S, Stern, HM, Wang, W, Kan, Z, Dbouk, HA, Peters, BA, Waring, P, Dela Vega, T, Kenski, DM, Bowman, KK, Lorenzo, M, Li, H, Wu, J, Modrusan, Z, Stinson, J, Eby, M, Yue, P, Kaminker, JS, de Sauvage, FJ, Backer, JM, Seshagiri, S	Cancer Cell	2009

External Reference Information

External Reference

UniProt:P27986 PIK3R1

Gene Names

PIK3R1, GRB1

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:5295 PIK3R1

COSMIC (genes):PIK3R1 PIK3R1

CTD Gene:5295 PIK3R1

dbSNP Gene:5295 PIK3R1

ENSEMBL:ENSG00000145675 PIK3R1

HGNC:8979 PIK3R1

KEGG Gene (Homo sapiens):5295 PIK3R1

Monarch:5295 PIK3R1

NCBI Gene:5295 PIK3R1

OMIM:171833 PIK3R1

UCSC:P27986 PIK3R1

Reference Transcript

Other Identifiers

0000770592

0001190184

0004610204

0005050156

11733017_a_at

11733018_s_at

11733019_a_at

11739539_a_at

11739540_a_at

11739541_a_at

11748670_a_at

11754631_x_at

1216

1269_at

16985518

1A0N

1AZG

1H9O

1PBW

1PHT

1PIC

1PKS

1PKT

212239_at

212240_s_at

212249_at

2813091

2813092

2813101

2813102

2813103

2813125

2813127

2813132

2813134

2813135

2813137

2813140

2813142

2813143

2813145

2813146

2813148

2813150

2813152

2813153

2813154

2813155

2813156

2813157

2813158

2813159

2IUG

2IUH

2IUI

2RD0

2V1Y

35373_at

3HHM

3HIZ

3I5R

3I5S

4268

44015_at

4A55

4JPS

4L1B

4L23

4L2Y

4OVU

4OVV

4WAF

4YKN

4ZOP

5295

55623_at

5AUL

5FI4

5GJI

5ITD

5M6U

5SW8

5SWG

5SWO

5SWP

5SWR

5SWT

5SX8

5SX9

5SXA

5SXB

5SXC

5SXD

5SXE

5SXF

5SXI

5SXJ

5SXK

5UBT

5UK8

5UKJ

5UL1

5VLR

5XGH

5XGI

5XGJ

6NCT

73148_at

73150_g_at

77475_at

8105778

A0A2X0SFG1

A_14_P105607

A_23_P144980

A_24_P29401

AAB04140

AAH30815

AAH94795

AAO15359

AC016564

AC104120

AF279367

AK094785

AK223613

BAD97333

BAG52931

BC030815

BC094795

CAB004268

CCDS3993

CCDS3994

CCDS3995

CCDS56374

CH471137

E5RGI8

E5RHI0

E5RJY0

E5RK66

EAW51312

EAW51313

ENSG00000145675

ENSP00000323512

ENSP00000338554

ENSP00000428056

ENSP00000429277

ENSP00000430098

ENST00000320694

ENST00000320694.12

ENST00000336483

ENST00000336483.9

ENST00000521381

ENST00000521381.5

ENST00000521657

ENST00000521657.5

ENST00000523872

ENST00000523872.1

EntrezGene:5295

EntrezGene:PIK3R1

GE58013

GE85962

GE88834

GO:0000902

GO:0001678

GO:0001784

GO:0001953

GO:0002376

GO:0003674

GO:0005068

GO:0005158

GO:0005159

GO:0005168

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005783

GO:0005794

GO:0005801

GO:0005829

GO:0005886

GO:0005911

GO:0005942

GO:0005943

GO:0006464

GO:0006468

GO:0006606

GO:0006629

GO:0006661

GO:0006810

GO:0006913

GO:0006950

GO:0007010

GO:0007155

GO:0007162

GO:0007165

GO:0007173

GO:0007186

GO:0007411

GO:0008134

GO:0008150

GO:0008219

GO:0008286

GO:0008625

GO:0008630

GO:0009058

GO:0014065

GO:0014068

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0019221

GO:0019899

GO:0019903

GO:0022607

GO:0030154

GO:0030168

GO:0030183

GO:0030234

GO:0030335

GO:0030674

GO:0031295

GO:0032760

GO:0032869

GO:0032991

GO:0033120

GO:0034641

GO:0034644

GO:0034976

GO:0035014

GO:0036312

GO:0038095

GO:0038096

GO:0038128

GO:0040011

GO:0042307

GO:0042592

GO:0043066

GO:0043125

GO:0043226

GO:0043548

GO:0043551

GO:0043559

GO:0043560

GO:0044403

GO:0045671

GO:0045944

GO:0046326

GO:0046626

GO:0046854

GO:0046935

GO:0046982

GO:0048009

GO:0048010

GO:0048015

GO:0048856

GO:0048870

GO:0050821

GO:0050852

GO:0050900

GO:0051492

GO:0051897

GO:0055085

GO:0060396

GO:1900103

GO:1903076

GO:1903078

GO:1990578

H0YB27

H0YBC2

HGNC:8979

HPA001216

Hs.6241.0.S1_3p_a_at

Hs.6241.0.S2_3p_at

Hs.6241.0.S3_3p_at

ILMN_1689057

ILMN_1691433

ILMN_1760303

ILMN_2289433

ILMN_2398235

IPR000198

IPR000980

IPR001452

IPR008936

IPR032498

IPR035020

IPR035022

IPR035591

IPR036028

IPR036860

LS482401

M61906

M61906_at

MIM:171833

MIM:269880

MIM:615214

MIM:616005

NM_001242466

NM_181504

NM_181523

NM_181524

NP_001229395

NP_852556

NP_852664

NP_852665

PF00017

PF00620

PF16454

PH_hs_0021977

PIK3R1

PIK3R1-201

PIK3R1-202

PIK3R1-211

PIK3R1-213

PIK3R1-216

PR00401

PR00678

SM00252

SM00324

SM00326

SPT35778

TC05000291.hg

U49349

UPI00000743EC

UPI000013D9FF

UPI000014094F

UPI0000E5AC63

XM_005248542

XM_011543493

XM_017009585

XM_017009586

XP_005248599

XP_011541795

XP_016865074

XP_016865075

Participant Of

hasCandidate

PIK3R1 iSH2 domain mutants [plasma membrane]

Other forms of this molecule

PIK3R1 G376R [plasma membrane]

PIK3R1 K379E [plasma membrane]

PIK3R1 Y463_L466del [plasma membrane]

PIK3R1 H450_E451del [plasma membrane]

PIK3R1 R574_T576del [plasma membrane]

PIK3R1 D560Y [plasma membrane]

PIK3R1 N564D [plasma membrane]

PIK3R1 K459del [plasma membrane]

PIK3R1 N564K [plasma membrane]

PIK3R1 R574I [plasma membrane]

PIK3R1 R574T [plasma membrane]

K63polyUb-PIK3R1 [cytosol]

PIK3R1 [plasma membrane]

PIK3R1 [cytosol]

Modified Residues

Name

L-aspartic acid 560 replaced with L-histidine

Coordinate

560

PsiMod

L-histidine residue [MOD:00018]

A protein modification that effectively converts a source amino acid residue to an L-histidine.

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

Disease

Name	Identifier	Synonyms
cancer	162	malignant tumor, malignant neoplasm, primary cancer
pharynx cancer	0060119

Cross References

RefSeq

NP_852665.1, XP_016865074.1, NP_852556.2, XP_005248599.1, NP_852664.1, NP_001229395.1

ZINC - World Drugs

P85A_HUMAN

OpenTargets

ENSG00000145675

ZINC - Substances

P85A_HUMAN

ZINC target

P27986

ZINC - Biogenic

P85A_HUMAN

PRO

P27986

PDB

1PBW, 4L23, 1AZG, 4A55, 5SW8, 2IUG, 2IUH, 5UL1, 3HIZ, 4L1B, 5SXK, 1A0N, 5UKJ, 5FI4, 4ZOP, 1PIC, 5GJI, 4OVV, 5VLR, 5SXJ, 5SXI, 4WAF, 5XGJ, 1H9O, 4OVU, 5UK8, 5SX9, 5SX8, 1PHT, 5UBT, 5SXF, 5XGI, 5XGH, 5SXE, 3I5S, 3I5R, 4JPS, 5SWT, 6NCT, 5SXD, 5SWR, 5SXC, 3HHM, 4L2Y, 1PKS, 2RD0, 1PKT, 5SWP, 6PYR, 5SWO, 6PYU, 5SXB, 2V1Y, 5SXA, 5AUL, 5ITD, 5SWG, 5M6U, 2IUI, 4YKN

ZINC - Metabolites

P85A_HUMAN

COSMIC

125378

GeneCards

P27986

ZINC - Predictions - Purchasable

P85A_HUMAN

Orphanet

22044

HMDB Protein

HMDBP03978

Interactors (70)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42336 PIK3CA	25	PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA [cytosol] (R-HSA-74787)	0.957	22
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.948	19
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940)	0.94	16
UniProt:P35568 IRS1	5	IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090) IRS1 [cytosol] (R-HSA-74769) p-Y-IRS1 [cytosol] (R-HSA-74772) p-Y-IRS1 [plasma membrane] (R-HSA-198366)	0.921	13
UniProt:P21860 ERBB3			0.921	41
UniProt:P10747 CD28	3	CD28 [plasma membrane] (R-HSA-167632) CD28 [cytosol] (R-HSA-167628) p-Y191-CD28 [plasma membrane] (R-HSA-388756)	0.903	10
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.863	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.829	6
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.822	7
UniProt:Q13480 GAB1	4	p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.796	33
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.794	10
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.779	6
UniProt:P10721 KIT	4	p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) p-8Y-KIT [plasma membrane] (R-HSA-1472116) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.77	19
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.752	4
UniProt:O00329 PIK3CD	2	PIK3CD [cytosol] (R-HSA-1806204) PIK3CD [plasma membrane] (R-HSA-392274)	0.744	6
UniProt:P62999 RAC1			0.717	5
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.688	3
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.688	11
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.688	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [cytosol] (R-HSA-57528) IRS2 [plasma membrane] (R-HSA-2428927) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.688	3
UniProt:P03496 NS	2	NS1 [cytosol] (R-FLU-169118) NS1 [nucleoplasm] (R-FLU-169113)	0.659	6
UniProt:P16410 CTLA4	2	CTLA4 [plasma membrane] (R-HSA-179764) p-Y165,Y182-CTLA4 [plasma membrane] (R-HSA-388754)	0.643	3
UniProt:P30874 SSTR2	1	SSTR2 [plasma membrane] (R-HSA-374757)	0.639	5
UniProt:Q9Y6W8 ICOS			0.623	5
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.623	6
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.623	5
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.611	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.609	2
UniProt:Q99152 VP3			0.591	3
UniProt:P16885 PLCG2	10	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.589	2
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.589	2
UniProt:P62994 Grb2	3	GRB2-1 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) GRB2-1 [cytosol] (R-RNO-74686)	0.589	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.589	3
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.589	2
UniProt:P43405 SYK	6	SYK [plasma membrane] (R-HSA-139844) p-Y-SYK [plasma membrane] (R-HSA-429432) p-6Y-SYK [cytosol] (R-HSA-983586) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.581	5
UniProt:P41970 ELK3			0.573	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.564	7
UniProt:O43493 TGOLN2	8	TGOLN2 [plasma membrane] (R-HSA-8864458) TGOLN2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869127) TGOLN2 [Golgi membrane] (R-HSA-434342) TGOLN2 [cytoplasmic vesicle membrane] (R-HSA-429818) TGOLN2 [trans-Golgi network membrane] (R-HSA-6811008) TGOLN2 [transport vesicle] (R-HSA-6811011) p-TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956886) TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956702)	0.564	2
UniProt:Q9UQC2 GAB2	4	GAB2 [cytosol] (R-HSA-508239) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y-GAB2 [cytosol] (R-HSA-912529) p-5Y-GAB2 [cytosol] (R-HSA-8855574)	0.564	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.564	2
UniProt:Q13111 CAF1A			0.564	2
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.564	2
UniProt:P35570 Irs1	7	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867) phospho-p-6Y-IRS1 [plasma membrane] (R-RNO-2445090) IRS1 [plasma membrane] (R-RNO-2425392) IRS1 [cytosol] (R-RNO-74769) phospho-p-Y-IRS1 [cytosol] (R-RNO-74772) phospho-p-Y-IRS1 [plasma membrane] (R-RNO-198366)	0.564	2
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.556	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.553	7
UniProt:Q13746 Q13746			0.544	3
UniProt:Q86VI4-3 LAPTM4B			0.524	2
UniProt:O15455 TLR3	6	TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endosome membrane] (R-HSA-2000341)	0.524	2
UniProt:Q8BM65-4 NYAP2			0.524	3
UniProt:Q8IY22 CMIP			0.524	2
UniProt:P48025 Syk	6	Syk [cytosol] (R-MMU-442293) phospho-p-Y-SYK [plasma membrane] (R-MMU-429432) p-Y348,Y352,Y525,Y526-Syk [cytosol] (R-MMU-5621123) phospho-p-6Y-SYK [cytosol] (R-MMU-983586) phospho-p-Y348-SYK [cytosol] (R-MMU-437953) SYK [cytosol] (R-MMU-58268)	0.524	2
UniProt:Q6PFX7 NYAP1			0.524	4
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.488	2
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.463	3
UniProt:P21145 MAL			0.463	3
UniProt:O00329-2 PIK3CD			0.463	2
UniProt:P30875	1	SSTR2 [plasma membrane] (R-MMU-374757)	0.462	2
UniProt:O14733 MAP2K7	4	MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.462	3
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.462	3
UniProt:P29350 PTPN6	5	PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641)	0.462	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2
UniProt:P06127 CD5			0.462	2
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.462	2
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293)	0.462	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.462	5
UniProt:P25963 NFKBIA	10	p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA [cytosol] (R-HSA-168151) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929) SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935)	0.462	2
UniProt:P32927 CSF2RB	6	CSF2RB [plasma membrane] (R-HSA-879960) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.462	4
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.462	4
UniProt:P04629 NTRK1	4	NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.462	2