PIK3R1 R574I [plasma membrane]

Stable Identifier
R-HSA-2399536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PIK3R1 Arg574Ile
Icon
PIK3R1 R574I [plasma membrane] icon
PIK3R1 R574I [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
General
Similar to other PIK3R1 iSH2 domain mutations found in cancer, substitution of arginine residue with isoleucine at position 574 of PIK3R1 is expected to relieve inhibitory effect on the catalytic subunit of PI3K, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 R574I mutant (Jaiswal et al. 2009).
Literature References
PubMed ID Title Journal Year
19962665 Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

Yue, P, Kaminker, JS, Kan, Z, Modrusan, Z, Dbouk, HA, Kenski, DM, Stinson, J, Waring, P, Janakiraman, V, Stern, HM, Wang, W, Jaiswal, BS, Lorenzo, M, Peters, BA, Seshagiri, S, Chaudhuri, S, Eby, M, Bowman, KK, Wu, J, Kljavin, NM, Dela Vega, T, Backer, JM, de Sauvage, FJ, Li, H

Cancer Cell 2009
External Reference Information
External Reference
UniProt:P27986 PIK3R1
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:, chain:2-724
Reference Genes
BioGPS Gene:5295 PIK3R1
COSMIC (genes):PIK3R1 PIK3R1
CTD Gene:5295 PIK3R1
dbSNP Gene:5295 PIK3R1
ENSEMBL:ENSG00000145675 PIK3R1
ENSEMBL_homo_sapiens_GENE:ENSG00000145675.16 PIK3R1
HGNC:8979 PIK3R1
KEGG Gene (Homo sapiens):5295 PIK3R1
Monarch:5295 PIK3R1
NCBI Gene:5295 PIK3R1
OMIM:171833 PIK3R1
UCSC:P27986 PIK3R1
Reference Transcript
Other Identifiers
11733017_a_at
11733018_s_at
11733019_a_at
11739539_a_at
11739540_a_at
11739541_a_at
11748670_a_at
11754631_x_at
1269_at
16985518
212239_PM_at
212239_at
212240_PM_s_at
212240_s_at
212249_PM_at
212249_at
2813091
2813092
2813093
2813094
2813095
2813101
2813102
2813103
2813125
2813127
2813132
2813134
2813135
2813137
2813139
2813140
2813142
2813143
2813145
2813146
2813148
2813150
2813152
2813153
2813154
2813155
2813156
2813157
2813158
2813159
35373_at
44015_at
5295
55623_at
73148_at
73150_g_at
77475_at
8105778
A_14_P105607
A_23_P144980
A_24_P29401
GE58013
GE85962
GE88834
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0002687
GO:0003824
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005886
GO:0005911
GO:0005942
GO:0005943
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0006955
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008286
GO:0008625
GO:0008630
GO:0010592
GO:0012501
GO:0015031
GO:0016020
GO:0016740
GO:0019209
GO:0019221
GO:0019903
GO:0023052
GO:0030154
GO:0030183
GO:0030217
GO:0030316
GO:0032760
GO:0032869
GO:0033120
GO:0034143
GO:0034330
GO:0034446
GO:0034644
GO:0034976
GO:0035014
GO:0035655
GO:0036312
GO:0042307
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043548
GO:0043559
GO:0043560
GO:0045671
GO:0045944
GO:0046326
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050821
GO:0051491
GO:0051492
GO:0051497
GO:0052742
GO:0055085
GO:0060090
GO:0060396
GO:0072659
GO:0097529
GO:0098542
GO:0098772
GO:0120183
GO:0140767
GO:0141038
GO:1900103
GO:1903076
GO:1903078
GO:1990578
HMNXSV003040338
Hs.6241.0.S1_3p_a_at
Hs.6241.0.S2_3p_at
Hs.6241.0.S3_3p_at
ILMN_1689057
ILMN_1691433
ILMN_1760303
ILMN_2289433
ILMN_2398235
M61906_at
PH_hs_0021977
RNA147745|p0849_imsncRNA655
TC05000291.hg
Participates
as a candidate of
Other forms of this molecule
p-Y-PIK3R1 [cytosol]
PIK3R1 G376R [plasma membrane]
PIK3R1 K379E [plasma membrane]
PIK3R1 Y463_L466del [plasma membrane]
PIK3R1 H450_E451del [plasma membrane]
PIK3R1 R574_T576del [plasma membrane]
PIK3R1 D560Y [plasma membrane]
PIK3R1 N564D [plasma membrane]
PIK3R1 K459del [plasma membrane]
PIK3R1 N564K [plasma membrane]
PIK3R1 D560H [plasma membrane]
PIK3R1 R574T [plasma membrane]
K63polyUb-PIK3R1 [cytosol]
PIK3R1 [cytosol]
PIK3R1 [plasma membrane]
Modified Residues
Name
L-arginine 574 replaced with L-isoleucine
Coordinate
574
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
L-isoleucine residue [MOD:00019]
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Metabolites
COSMIC
HPA
GeneCards
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (78)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42336 PIK3CA  20 0.967 64
 UniProt:P09619 PDGFRB  3 0.951 21
 UniProt:P22681 CBL  20 0.94 16
 UniProt:P35568 IRS1  5 0.921 13
 UniProt:P21860 ERBB3      0.921 41
 UniProt:P10747 CD28  3 0.903 10
 UniProt:O00329 PIK3CD  2 0.888 9
 UniProt:P62993 GRB2  1 0.863 6
 UniProt:P42338 PIK3CB  1 0.84 6
 UniProt:P29353 SHC1  5 0.816 6
 UniProt:P00533 EGFR  20 0.81 7
 UniProt:P08069 IGF1R  3 0.803 6
 UniProt:Q13480 GAB1  4 0.796 33
 UniProt:P60953 CDC42  3 0.794 10
 UniProt:P12931 SRC  6 0.779 7
 UniProt:P06213 INSR  6 0.767 5
 UniProt:P04626 ERBB2  20 0.759 12
 UniProt:P10721 KIT  20 0.749 19
 UniProt:P62999  6 0.717 5
 UniProt:Q9Y4H2 IRS2  4 0.688 3
 UniProt:P62994 Grb2  3 0.688 3
 UniProt:P03496 NS  2 0.659 6
 UniProt:P11362 FGFR1  9 0.644 6
 UniProt:O14654 IRS4  2 0.643 3
 UniProt:P16410 CTLA4  2 0.643 3
 UniProt:P30874 SSTR2  1 0.639 5
 UniProt:P04629 NTRK1  4 0.624 4
 UniProt:O00459 PIK3R2  3 0.623 4
 UniProt:Q9Y6W8 ICOS  1 0.623 5
 UniProt:P45983 MAPK8  3 0.623 6
 UniProt:P10398 ARAF  4 0.611 3
 UniProt:Q8TDQ0 HAVCR2  1 0.597 3
 UniProt:P30530 AXL  2 0.597 3
 UniProt:Q99152 VP3      0.591 3
 UniProt:P61981 YWHAG  1 0.589 2
 UniProt:P43405 SYK  6 0.581 5
 UniProt:P41970 ELK3      0.573 2
 UniProt:P48023 FASLG  1 0.571 2
 UniProt:P29376 LTK  2 0.569 3
 UniProt:Q13111 CAF1A      0.564 2
 UniProt:P35570 Irs1  7 0.564 2
 UniProt:Q9UQC2 GAB2  5 0.564 2
 UniProt:P19793 RXRA  4 0.556 8
 UniProt:P42858 HTT  1 0.553 7
 UniProt:Q13746 Q13746      0.544 3
 UniProt:P16885 PLCG2  8 0.536 2
 UniProt:O43493 TGOLN2  8 0.536 2
 UniProt:Q07889 SOS1  3 0.536 3
 UniProt:P46109 CRKL  2 0.536 2
 UniProt:Q92569 PIK3R3  2 0.527 2
 UniProt:P63104 YWHAZ  2 0.527 2
 UniProt:P09564 CD7      0.527 2
 UniProt:Q86VI4-3 LAPTM4B      0.524 2
 UniProt:Q8BM65-4 NYAP2      0.524 3
 UniProt:Q8IY22 CMIP      0.524 2
 UniProt:Q6PFX7 NYAP1      0.524 4
 UniProt:O15455 TLR3  6 0.524 2
 UniProt:P48025 Syk  8 0.524 2
 UniProt:P21709 EPHA1  2 0.519 2
 UniProt:P17948 FLT1  1 0.519 3
 UniProt:Q9Y2I1 NISCH  1 0.508 2
 UniProt:P43626 KIR2DL1  1 0.488 2
 UniProt:P03372 ESR1  10 0.483 7
 UniProt:Q01973 ROR1  2 0.483 2
 UniProt:P46108 CRK  1 0.483 2
 UniProt:P21145 MAL      0.463 3
 UniProt:O00329-2 PIK3CD      0.463 2
 UniProt:P58753 TIRAP  2 0.463 3
 UniProt:P30875  1 0.462 2
 UniProt:P06127 CD5      0.462 2
 UniProt:P45984 MAPK9  3 0.462 3
 UniProt:O14733 MAP2K7  4 0.462 3
 UniProt:Q16584 MAP3K11  1 0.462 3
 UniProt:O43561 LAT  3 0.462 4
 UniProt:P63000 RAC1  6 0.462 5
 UniProt:P25963 NFKBIA  9 0.462 2
 UniProt:P32927 CSF2RB  6 0.462 4
 UniProt:P29350 PTPN6  5 0.462 2
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