PIK3R1 R574_T576del [plasma membrane]

Stable Identifier
R-HSA-2399544
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
PIK3R1 Arg574_Thr576del
Locations in the PathwayBrowser
General

The inframe deletion of amino acid residues at position 574 to 576 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 R574_T576del mutant (Urick et al. 2011).

Literature References
PubMed ID Title Journal Year
21478295 PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer

Urick, ME, Rudd, ML, Godwin, AK, Sgroi, D, Merino, M, Bell, DW

Cancer Res. 2011
External Reference Information
External Reference
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:1, chain:2-724
Other Identifiers
0000770592
0001190184
0004610204
0005050156
11733017_a_at
11733018_s_at
11733019_a_at
11739539_a_at
11739540_a_at
11739541_a_at
11748670_a_at
11754631_x_at
1216
1269_at
16985518
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
212239_at
212240_s_at
212249_at
2813092
2813101
2813102
2813103
2813125
2813127
2813132
2813134
2813135
2813137
2813140
2813142
2813143
2813145
2813146
2813148
2813150
2813152
2813153
2813154
2813155
2813156
2813157
2813158
2813159
2IUG
2IUH
2IUI
2RD0
2V1Y
35373_at
3HHM
3HIZ
3I5R
3I5S
4268
44015_at
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5295
55623_at
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
73148_at
73150_g_at
77475_at
8105778
A0A2X0SFG1
A_14_P105607
A_23_P144980
A_24_P29401
AAB04140
AAH30815
AAH94795
AAO15359
AC016564
AC104120
AF279367
AK094785
AK223613
BAD97333
BAG52931
BC030815
BC094795
CAB004268
CCDS3993
CCDS3994
CCDS3995
CCDS56374
CH471137
E5RGI8
E5RHI0
E5RJY0
E5RK66
EAW51312
EAW51313
ENSG00000145675
ENSP00000323512
ENSP00000338554
ENSP00000428056
ENSP00000429277
ENSP00000430098
ENST00000320694
ENST00000320694.12
ENST00000336483
ENST00000336483.9
ENST00000521381
ENST00000521381.5
ENST00000521657
ENST00000521657.5
ENST00000523872
ENST00000523872.1
EntrezGene:5295
GE58013
GE85962
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0003674
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005575
GO:0005634
GO:0005737
GO:0005801
GO:0005829
GO:0005886
GO:0005911
GO:0005942
GO:0005943
GO:0006464
GO:0006468
GO:0006606
GO:0006629
GO:0006661
GO:0006810
GO:0006913
GO:0006950
GO:0007162
GO:0007165
GO:0007173
GO:0007186
GO:0007411
GO:0008134
GO:0008286
GO:0008625
GO:0008630
GO:0009058
GO:0014065
GO:0014068
GO:0015031
GO:0016020
GO:0016032
GO:0019221
GO:0019899
GO:0019903
GO:0030154
GO:0030168
GO:0030183
GO:0030234
GO:0030335
GO:0030674
GO:0031295
GO:0032760
GO:0032869
GO:0032991
GO:0033120
GO:0034644
GO:0034976
GO:0035014
GO:0036312
GO:0038095
GO:0038096
GO:0038128
GO:0040011
GO:0042307
GO:0042592
GO:0043066
GO:0043125
GO:0043226
GO:0043548
GO:0043551
GO:0043559
GO:0043560
GO:0044403
GO:0045671
GO:0045944
GO:0046326
GO:0046626
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048010
GO:0048015
GO:0048870
GO:0050821
GO:0050852
GO:0050900
GO:0051492
GO:0051897
GO:0060396
GO:1900103
GO:1903076
GO:1903078
GO:1990578
H0YB27
H0YBC2
HGNC:8979
HPA001216
Hs.6241.0.S1_3p_a_at
Hs.6241.0.S2_3p_at
Hs.6241.0.S3_3p_at
ILMN_1689057
ILMN_1691433
ILMN_1760303
ILMN_2289433
ILMN_2398235
IPR000198
IPR000980
IPR001452
IPR001720
IPR008936
IPR032498
IPR035020
IPR035022
IPR035591
IPR036028
IPR036860
LS482401
M61906
M61906_at
MIM:171833
MIM:269880
MIM:615214
MIM:616005
NM_001242466
NM_181504
NM_181523
NM_181524
NP_001229395
NP_852556
NP_852664
NP_852665
PF00017
PF00620
PF16454
PH_hs_0021977
PIK3R1
PIK3R1-201
PIK3R1-202
PIK3R1-211
PIK3R1-213
PIK3R1-216
PR00401
PR00678
SM00252
SM00324
SM00326
SPT35778
TC05000291.hg
U49349
UPI00000743EC
UPI000013D9FF
UPI000014094F
UPI0000E5AC63
XM_005248542
XM_011543493
XM_017009585
XM_017009586
XP_005248599
XP_011541795
XP_016865074
XP_016865075
Participant Of
Other forms of this molecule
Modified Residues
Name
Deletion of residues 574 to 576
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
endometrial cancer 1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
Cross References
ZINC - World Drugs
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Metabolites
COSMIC
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (70)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42336 PIK3CA  25 0.957 22
 UniProt:P09619 PDGFRB  3 0.948 19
 UniProt:P22681 CBL  6 0.94 16
 UniProt:P21860 ERBB3      0.921 41
 UniProt:P35568 IRS1  5 0.921 13
 UniProt:P10747 CD28  3 0.903 10
 UniProt:P62993 GRB2  1 0.863 6
 UniProt:P29353 SHC1  5 0.829 6
 UniProt:P12931 SRC  6 0.822 7
 UniProt:Q13480 GAB1  4 0.796 33
 UniProt:P60953 CDC42  3 0.794 10
 UniProt:P00533 EGFR  58 0.779 6
 UniProt:P10721 KIT  4 0.77 19
 UniProt:P08069 IGF1R  3 0.752 4
 UniProt:O00329 PIK3CD  2 0.744 6
 UniProt:P62999 RAC1      0.717 5
 UniProt:P42338 PIK3CB  1 0.688 3
 UniProt:P06213 INSR  6 0.688 3
 UniProt:Q9Y4H2 IRS2  4 0.688 3
 UniProt:P04626 ERBB2  12 0.688 11
 UniProt:P03496 NS  2 0.659 6
 UniProt:P16410 CTLA4  2 0.643 3
 UniProt:P30874 SSTR2  1 0.639 5
 UniProt:Q9Y6W8 ICOS      0.623 5
 UniProt:P11362 FGFR1  8 0.623 5
 UniProt:P45983 MAPK8  3 0.623 6
 UniProt:P10398 ARAF  4 0.611 3
 UniProt:P48023 FASLG  1 0.609 2
 UniProt:Q99152 VP3      0.591 3
 UniProt:P49023 PXN  4 0.589 2
 UniProt:P62994 Grb2  3 0.589 2
 UniProt:P61981 YWHAG  1 0.589 2
 UniProt:P46109 CRKL  2 0.589 2
 UniProt:P16885 PLCG2  10 0.589 2
 UniProt:Q07889 SOS1  3 0.589 3
 UniProt:P43405 SYK  6 0.581 5
 UniProt:P41970 ELK3      0.573 2
 UniProt:P03372 ESR1  8 0.564 7
 UniProt:O43493 TGOLN2  8 0.564 2
 UniProt:Q13111 CAF1A      0.564 2
 UniProt:P17948 FLT1  1 0.564 2
 UniProt:P46108 CRK  1 0.564 2
 UniProt:Q9UQC2 GAB2  4 0.564 2
 UniProt:P35570 Irs1  7 0.564 2
 UniProt:P19793 RXRA  3 0.556 8
 UniProt:P42858 HTT  1 0.553 7
 UniProt:Q13746 Q13746      0.544 3
 UniProt:Q86VI4-3 LAPTM4B      0.524 2
 UniProt:Q8BM65-4 NYAP2      0.524 3
 UniProt:Q8IY22 CMIP      0.524 2
 UniProt:Q6PFX7 NYAP1      0.524 4
 UniProt:O15455 TLR3  6 0.524 2
 UniProt:P48025 Syk  6 0.524 2
 UniProt:P43626 KIR2DL1  1 0.488 2
 UniProt:P21145 MAL      0.463 3
 UniProt:O00329-2 PIK3CD      0.463 2
 UniProt:P58753 TIRAP  2 0.463 3
 UniProt:P30875  1 0.462 2
 UniProt:P06127 CD5      0.462 2
 UniProt:P30530 AXL  2 0.462 2
 UniProt:P45984 MAPK9  3 0.462 3
 UniProt:P63000 RAC1  6 0.462 5
 UniProt:P32927 CSF2RB  6 0.462 4
 UniProt:O43561 LAT  3 0.462 4
 UniProt:Q8TDQ0 HAVCR2  1 0.462 2
 UniProt:P04629 NTRK1  4 0.462 2
 UniProt:P29350 PTPN6  5 0.462 2
 UniProt:P25963 NFKBIA  10 0.462 2
 UniProt:O14733 MAP2K7  4 0.462 3
 UniProt:Q16584 MAP3K11  1 0.462 3