Reactome: A Curated Pathway Database

AKT1 E17K mutant phosphorylates BAD

Stable Identifier
R-HSA-2399941
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant phosphorylates BAD (Guo et al. 2010). AKT-mediated BAD phosphorylation inactivates BAD, thereby preventing BAD-mediated apoptosis (Del Peso et al. 1997).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol] p-T308,S473-AKT1 E17K [cytosol] protein serine/threonine kinase activity (0004674)
Disease
Diseases
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer