AKT1 E17K mutant phosphorylates BAD

Stable Identifier
R-HSA-2399941
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant phosphorylates BAD (Guo et al. 2010). AKT-mediated BAD phosphorylation inactivates BAD, thereby preventing BAD-mediated apoptosis (Del Peso et al. 1997).

Literature References
PubMed ID Title Journal Year
9381178 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

del Peso, L, Gonzalez-Garcia, M, Page, CP, Herrera, R, Nunez, G

Science 1997
20440266 Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells

Guo, G, Qiu, X, Wang, S, Chen, Y, Chen, Y, Rothman, PB, Wang, Z, Wang, G, Chen, JL

Oncogene 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed