Reactome: A Curated Pathway Database

AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)

Stable Identifier
R-HSA-2399977
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant is expected to phosphorylate AKT1S1 (PRAS40), like the wild-type AKT (Kovacina et al. 2003), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol] p-T308,S473-AKT1 E17K [cytosol] protein serine/threonine kinase activity (0004674)
Disease
Diseases
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer