Reactome: A Curated Pathway Database

AKT1 E17K mutant phosphorylates MDM2

Stable Identifier
R-HSA-2399981
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant is expected to phosphorylate MDM2, like the wild-type AKT (Zhou et al. 2001, Feng et al. 2004, Milne et al. 2004), but this has not been experimentally tested.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol] p-T308,S473-AKT1 E17K [cytosol] protein serine/threonine kinase activity (0004674)
Disease
Diseases
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer