AKT1 E17K mutant phosphorylates caspase-9

Stable Identifier
R-HSA-2399985
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant is expected to phosphorylate caspase-9 (CASP9), like the wild-type AKT (Cardone et al. 1998), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
9812896 Regulation of cell death protease caspase-9 by phosphorylation Science 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer