AKT1 E17K mutant phosphorylates NR4A1 (NUR77)

Stable Identifier
R-HSA-2399988
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant is expected to phosphorylate NR4A1, like the wild-type AKT (Pekarsky et al. 2001), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77 Proc Natl Acad Sci U S A 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer