AKT1 E17K mutant phosphorylates forkhead box transcription factors

Stable Identifier
R-HSA-2399992
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT1 E17K gain-of-function mutant phosphorylates FOXO3 (Carpten et al. 2007), and is expected to phosphorylate other forkhead box transcription factor family members, FOXO1 and FOXO4, like the wild-type AKT (Brunet et al. 1999, Rena et al. 1999, Matsuzaki et al. 2005), but this has not been experimentally tested.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer