Reactome | LRAT esterifies RBP1:atROL and FACYLs to atREs

LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier

R-HSA-2404137

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, plasma membrane, lipid droplet

ReviewStatus

5/5

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LRAT esterifies RBP1:atROL and FACYLs to atREs

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All-trans-retinyl esters (atREs) are the main storage form of retinol in hepatic stellate cells (HSCs). Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) with a variety of fatty acyl groups (FACYLs) to form REs which are stored in lipid droplets in the cytosol. Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9920938	Molecular and biochemical characterization of lecithin retinol acyltransferase. Rando, RR, Ruiz, A, Lim, YH, Gilbert, BA, Winston, A, Bok, D	J Biol Chem	1999