LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier
R-HSA-2404137
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

All-trans-retinyl esters (atREs) are the main storage form of retinol in hepatic stellate cells (HSCs). Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) with a variety of fatty acyl groups (FACYLs) to form REs which are stored in lipid droplets in the cytosol. Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999).

Literature References
PubMed ID Title Journal Year
9920938 Molecular and biochemical characterization of lecithin retinol acyltransferase.

Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D

J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
O-palmitoyltransferase activity of LRAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed