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LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier
R-HSA-2404137
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

All-trans-retinyl esters (atREs) are the main storage form of retinol in hepatic stellate cells (HSCs). Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) with a variety of fatty acyl groups (FACYLs) to form REs which are stored in lipid droplets in the cytosol. Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999).

Literature References
PubMed ID Title Journal Year
9920938 Molecular and biochemical characterization of lecithin retinol acyltransferase. J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
O-palmitoyltransferase activity of LRAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events