NREH hydrolyses atREs to atROL and FAs

Stable Identifier
R-HSA-2404140
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Retinyl esters are hydrolysed to retinol in hepatocytes
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Summation

Once inside liver parenchymal cells, all-trans-retinyl esters (atREs), are hydrolysed to all-trans-retinol (atROL) and fatty acids (FAs) by a neutral, all-trans-retinyl ester hydrolase (NREH). No NREH has been characterised yet although both acidic and neutral REH activity has been shown to be associated with endosomes and plasma membrane preparations from rodent livers (Harrison & Gad 1989, Gad & Harrison 1991, Hagen et al. 1999). As the acidity increases, early endosomes change to late endosomes and further hydrolysis of atREs is mediated by acid retinyl ester hydrolase (AREH). Like NREH, AREH has not yet been characterised (see refs above). The translocation mechanism of atROL to cytosol is unknown.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity of NREH [early endosome]
Physical Entity
Activity
Authored
Reviewed