atROL binds RBP1

Stable Identifier
R-HSA-2404142
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

All-trans-retinol (atROL) is stored in hepatic stellate cells (HSCs) in its esterified form. Before esterification takes place, atROL binds to cellular retinol-binding protein 1 (RBP1) (Folli et al. 2001). The resultant complex (RBP1:atROL) serves as a substrate for lecithin retinol acyltransferase (LRAT), the main enzyme responsible for the esterification of atROL. It is thought the binding of RBP1 serves to translocate atROL to the endoplasmic reticulum where LRAT is located.

Literature References
PubMed ID Title Journal Year
11274389 Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein

Folli, C, Calderone, V, Ottonello, S, Bolchi, A, Zanotti, G, Stoppini, M, Berni, R

Proc. Natl. Acad. Sci. U.S.A. 2001
9920938 Molecular and biochemical characterization of lecithin retinol acyltransferase.

Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D

J Biol Chem 1999
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