Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

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R-HSA-2404192
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Homo sapiens
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Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012).

Literature References
PubMed ID Title Journal Year
20098959 Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain

Parrella, E, Longo, VD

ScientificWorldJournal 2010
22649417 Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances

Siddle, K

Front Endocrinol (Lausanne) 2012
20975071 Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

Maki, RG

J. Clin. Oncol. 2010
22044904 Igf-I signaling and effects on longevity

Holzenberger, M

Nestle Nutr Workshop Ser Pediatr Program 2011
17598937 Biological & physiological aspects of action of insulin-like growth factor peptide family

Pavelić, J, Matijević, T, Knezević, J

Indian J. Med. Res. 2007
21042815 The IGF system

Annunziata, M, Granata, R, Ghigo, E

Acta Diabetol 2011
18927274 The type 1 insulin-like growth factor receptor pathway

Chitnis, MM, Yuen, JS, Protheroe, AS, Pollak, M, Macaulay, VM

Clin. Cancer Res. 2008
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