Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK

Stable Identifier
R-HSA-2408507
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+. PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer. This reaction involving PSTK is inferred from the equivalent reaction in mouse.
Literature References
PubMed ID Title Journal Year
15317934 Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

Carlson, BA, Kryukov, GV, Berry, MJ, Hatfield, DL, Rao, M, Gladyshev, VN, Xu, XM

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Participates
Catalyst Activity

seryl-selenocysteinyl-tRNA kinase activity of PSTK:Mg2+ [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!