Metabolism of ingested SeMet, Sec, MeSec into H2Se

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R-HSA-2408508
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Pathway
Species
Homo sapiens
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Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).

Literature References
PubMed ID Title Journal Year
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Pinto, JT, Lee, JI, Sinha, R, MacEwan, ME, Cooper, AJ

Amino Acids 2011
6456763 Enzymatic synthesis of selenocysteine in rat liver

Esaki, N, Nakamura, T, Tanaka, H, Suzuki, T, Morino, Y, Soda, K

Biochemistry 1981
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