Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome

Stable Identifier
R-HSA-2408529
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
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The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This reaction is inferred from events occurring in rats.
Literature References
PubMed ID Title Journal Year
15821744 Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes

Chavatte, L, Driscoll, DM, Brown, BA

Nat. Struct. Mol. Biol. 2005
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Catalyst Activity

selenocysteine insertion sequence binding activity of SECISBP2 [cytosol]

Physical Entity
SECISBP2 [cytosol] (Homo sapiens)
Activity
selenocysteine insertion sequence binding (GO:0035368)
Inferred From
Sec-tRNA(Sec):Eefsec:GTP binds to Rpl30 (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Hill, DP  (2025-02-25)
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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