MeSeH is hydrolysed to H2Se by methylselenol demethylase

Stable Identifier
R-HSA-2408530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A yet to be identified enzyme with methylselenol demethylase (MSDM) activity is involved in the hydrolysis of methylselenol aka methaneselenol (MeSeH) into hydrogen selenide (H2Se) and methanol. This reaction is inferred from the event in rat (Suzuki et al. 2007, Ohta and Suzuki 2008).

Literature References
PubMed ID Title Journal Year
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Kurasaki, K, Suzuki, N

Biochim. Biophys. Acta 2007
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Ohta, Y, Suzuki, KT

Toxicol. Appl. Pharmacol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methylselenol demethylase activity of MSDM [cytosol]
Physical Entity
Activity
Inferred From
Authored
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Created