Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH

Stable Identifier
R-HSA-2408537
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Excess selenomethionine (SeMet) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and 2-oxobutanoic acid. This reaction is inferred from the event in mouse involving the protein cystathionine gamma-lyase (Cth) (Okuno et al. 2001, Okuno et al. 2005, Okuno et al. 2006).

Literature References
PubMed ID Title Journal Year
16444005 Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver

Okuno, T, Ueno, H, Nakamuro, K

Biol Trace Elem Res 2006
11578145 Contribution of enzymic alpha, gamma-elimination reaction in detoxification pathway of selenomethionine in mouse liver

Okuno, T, Kubota, T, Kuroda, T, Ueno, H, Nakamuro, K

Toxicol. Appl. Pharmacol. 2001
16037612 Purification and characterization of mouse hepatic enzyme that converts selenomethionine to methylselenol by its alpha,gamma-elimination

Okuno, T, Motobayashi, S, Ueno, H, Nakamuro, K

Biol Trace Elem Res 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
selenomethionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]
Physical Entity
Activity
Inferred From
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Reviewed
Created