AdoSeMet is converted to AdeSeHCys by MetTrans(1)

Stable Identifier
R-HSA-2408544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A set of methyltransferases (MetTrans(1)) consisting of the proteins histamine-N-methyltransferase (HNMT), glycine-N-methyltransferase (GNMT), and nicotinamide-N-methyltransferase (NNMT) remove a methyl group from adenosylselenomethionine (AdoSeMet) to leave adenosylselenohomocysteine (AdeSeHCys). This reaction is inferred from the event in rat involving the set of methyltransferases (MetTrans(2)) consisting of the proteins histamine-N-methyltransferase (Hnmt), glycine-N-methyltransferase (Gnmt), and nicotinamide-N-methyltransferase (Nnmt) (Kajander et al. 1991).

Literature References
PubMed ID Title Journal Year
1711890 Metabolism, cellular actions, and cytotoxicity of selenomethionine in cultured cells

Kajander, EO, Harvima, RJ, Eloranta, TO, Martikainen, H, Kantola, M, Kärenlampi, SO, Akerman, KK

Biol Trace Elem Res 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
selenol Se-methyltransferase activity of MetTrans(1) [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created