tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex

Stable Identifier
R-HSA-2408546
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As a first step in the incorporation of selenomethionine into proteins, tRNA(Met) is converted into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)) by methionine-tRNA ligase (MARS) component of a multisynthetase complex comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. It is involved in the selenomethionylation of tRNA(Met) into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)). This reaction is inferred from the event in mung bean (Burnell 1981) and in wheat germ (Eustice et al. 1981).

Literature References
PubMed ID Title Journal Year
16661668 Methionyl-tRNA Synthetase from Phaseolus aureus: Purification and Properties

Burnell, JN

Plant Physiol. 1981
16661782 Selenium toxicity: aminoacylation and Peptide bond formation with selenomethionine

Eustice, DC, Kull, FJ, Shrift, A

Plant Physiol. 1981
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
selenomethionine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created