Selenocysteine synthesis

Stable Identifier
R-HSA-2408557
Type
Pathway
Species
Homo sapiens
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Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

Literature References
PubMed ID Title Journal Year
20623998 Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis

Palioura, S, Herkel, J, Simonovic, M, Lohse, AW, Söll, D

Biol. Chem. 2010
19747061 Threading the needle: getting selenocysteine into proteins

Donovan, J, Copeland, PR

Antioxid. Redox Signal. 2010
18252769 From one amino acid to another: tRNA-dependent amino acid biosynthesis

Sheppard, K, Yuan, J, Hohn, MJ, Jester, B, Devine, KM, Söll, D

Nucleic Acids Res. 2008
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