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SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, binds Collagen type I, hydroxyapatite and Ca2+, suggesting a role in the mineralization of bone and cartilage (Termine et al. 1981). It is expressed by osteoblasts, odontoblasts, and many other cell types (Romanowski et al. 1990, Mundlos et al. 1992, Papagerakis et al. 2002). SPARC expression has been used to follow the progression of osteoblast cytodifferentiation.

Literature References
PubMed ID Title Journal Year
2364322 Immunoelectron microscopy of osteonectin and type I collagen in osteoblasts and bone matrix Calcif. Tissue Int. 1990
Participant Of
Orthologous Events