Reactome | LRP1 [plasma membrane]

LRP1 [plasma membrane]

Stable Identifier

R-HSA-2424272

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Prolow-density lipoprotein receptor-related protein 1, LRP1_HUMAN

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External Reference Information

External Reference

UniProt:Q07954 LRP1

Gene Names

LRP1, A2MR, APR

Chain

signal peptide:1-19, chain:20-4544, chain:20-3943, chain:3944-4544, chain:4441-4544

Reference Genes

BioGPS Gene:4035 LRP1

COSMIC (genes):LRP1 LRP1

CTD Gene:4035 LRP1

dbSNP Gene:4035 LRP1

ENSEMBL:ENSG00000123384 LRP1

HGNC:6692 LRP1

KEGG Gene (Homo sapiens):4035 LRP1

Monarch:4035 LRP1

NCBI Gene:4035 LRP1

OMIM:107770 LRP1

UCSC:Q07954 LRP1

Reference Transcript

RefSeq:NM_002332.2 LRP1

Other Identifiers

0001050494

11715533_a_at

11715534_a_at

11760039_a_at

1555353_at

16752715

200784_s_at

200785_s_at

3417843

3417844

3417849

3417850

3417852

3417853

3417854

3417855

3417857

3417858

3417859

3417860

3417862

3417863

3417866

3417867

3417868

3417869

3417870

3417871

3417872

3417877

3417878

3417881

3417882

3417884

3417886

3417887

3417888

3417889

3417891

3417892

3417894

3417896

3417897

3417898

3417900

3417901

3417902

3417903

3417905

3417909

3417910

3417911

3417912

3417915

3417916

3417917

3417918

3417920

3417921

3417922

3417923

3417924

3417925

3417927

3417928

3417929

3417931

3417932

3417933

3417935

3417936

3417937

3417938

3417939

3417940

3417941

3417942

3417943

3417944

3417945

3417946

3417947

3417948

3417949

3417950

3417951

3417952

3417955

3417956

3417959

3417960

3417962

3417963

3417964

3417965

3417967

3417968

3417970

3417972

3417973

3417974

3417975

3417977

3417978

3417979

3417981

3417982

3417983

3417984

3417985

3417986

3417987

38775_at

4035

7956301

A_14_P111898

A_23_P124837

A_33_P3391105

GE59712

GO:0000902

GO:0001523

GO:0001540

GO:0002020

GO:0002265

GO:0002376

GO:0003674

GO:0003723

GO:0005041

GO:0005044

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005856

GO:0005886

GO:0005887

GO:0005905

GO:0005925

GO:0006464

GO:0006629

GO:0006810

GO:0006897

GO:0006898

GO:0006909

GO:0006950

GO:0007010

GO:0007034

GO:0007041

GO:0007155

GO:0007165

GO:0007204

GO:0007205

GO:0007267

GO:0007275

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0010715

GO:0010812

GO:0010875

GO:0010942

GO:0010976

GO:0010977

GO:0014912

GO:0015026

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0016323

GO:0016964

GO:0019899

GO:0021987

GO:0022607

GO:0030054

GO:0030136

GO:0030154

GO:0030178

GO:0030198

GO:0030226

GO:0030425

GO:0030666

GO:0031410

GO:0031623

GO:0032050

GO:0032092

GO:0032370

GO:0032374

GO:0032429

GO:0032593

GO:0032956

GO:0032991

GO:0034185

GO:0034330

GO:0035774

GO:0035909

GO:0038023

GO:0038024

GO:0040007

GO:0040011

GO:0042157

GO:0042592

GO:0042953

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0043277

GO:0043395

GO:0043524

GO:0044242

GO:0044295

GO:0044877

GO:0045056

GO:0045177

GO:0045202

GO:0045773

GO:0045807

GO:0046872

GO:0048691

GO:0048694

GO:0048856

GO:0048870

GO:0050766

GO:0051222

GO:0051481

GO:0051895

GO:0060548

GO:0061642

GO:0070325

GO:0070374

GO:0097242

GO:0098797

GO:0150051

GO:0150093

GO:0150094

GO:0150104

GO:1900149

GO:1900223

GO:1903078

GO:1904109

GO:1904300

GO:1904646

GO:1904754

GO:1905049

GO:1905167

GO:2000587

Hs.89137.0.A1_3p_a_at

Hs2Affx.1.232.S1_3p_s_at

ILMN_1669772

PH_hs_0022761

TC12000521.hg

TC12002395.hg

TC12002396.hg

X13916_at

g4758685_3p_s_at

Participant Of

hasMember

LRPs [plasma membrane]

Other forms of this molecule

LRP1 [endocytic vesicle membrane]

LRP1 [plasma membrane]

Inferred To

Lrp1 [plasma membrane] (Mus musculus)

Lrp1 [plasma membrane] (Rattus norvegicus)

lrp1ab [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002323.2

OpenTargets

ENSG00000123384

HPA

ENSG00000123384-LRP1

GeneCards

Q07954

Ensembl

ENSG00000123384, ENST00000243077, ENSP00000341264, ENSP00000243077, ENST00000338962

PRO

Q07954

Orphanet

23577

HMDB Protein

HMDBP07785

PDB

2KNY, 2FYJ, 2KNX, 1D2L, 1CR8, 1J8E, 2FYL

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02649 APOE	9	APOE [endosome lumen] (R-HSA-174804) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.784	23
UniProt:P30533 AMRP			0.75	4
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.704	4
calcium(2+) [ChEBI:29108]	19	Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [extracellular region] (R-ALL-74112) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [cytosol] (R-ALL-74016)	0.609	4
UniProt:Q15485 FCN2	1	FCN2 [extracellular region] (R-HSA-2530438)	0.558	2
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.558	5
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q92685 ALG3	5	ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 [endoplasmic reticulum membrane] (R-HSA-449287)	0.508	2
UniProt:Q03350	4	Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173234) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173187) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173111) Thbs2 [extracellular region] (R-MMU-66520)	0.499	2
UniProt:Q63722	1	Jag1 [plasma membrane] (R-RNO-9013079)	0.499	4

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