SOS mediated nucleotide exchange of RAS (SHC)

Stable Identifier
R-HSA-2424477
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GRB2-bound SOS promotes the formation of active GTP-bound RAS. This activates the mitogen-activated protein kinase (MAPK) cascade, leading to cell growth and differentiation.

Literature References
PubMed ID Title Journal Year
9690470 The structural basis of the activation of Ras by Sos

Boriack-Sjodin, PA, Margarit, SM, Bar-Sagi, D, Kuriyan, J

Nature 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created