Phosphorylation of BTK by p-SYK

Stable Identifier
R-HSA-2424484
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of BTK by p-SYK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In myeloid cells BTK is phosphorylated on Y551 upon DAP12 activation in a SYK kinase-dependent manner. Y551 is located in the activation loop of BTK, known to be required for activation and kinase activity. Y223 in the SH3 domain of BTK is autophosphorylated, which may also be involved in BTK activation (Ormsby et al. 2010, Rawlings et al. 1996).
Literature References
PubMed ID Title Journal Year
21659545 Btk is a positive regulator in the TREM-1/DAP12 signaling pathway

Tessarz, AS, Schlecker, E, Schulze, I, Angelisová, P, Borte, M, Ormsby, T, Horejsí, V, Cerwenka, A, Köprülü, AD, Ferdin, J, Ellmeier, W, Warnatz, K

Blood 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]

Physical Entity
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of BTK by p-SYK (Canis familiaris)
Phosphorylation of BTK by p-SYK (Gallus gallus)
Phosphorylation of BTK by p-SYK (Mus musculus)
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
Phosphorylation of BTK by p-SYK (Sus scrofa)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-07-23)
Cite Us!