SREBP1A,1C binds the FASN promoter

Stable Identifier
R-HSA-2426148
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
SREBF1A,1C binds the FASN promoter
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SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).

Literature References
PubMed ID Title Journal Year
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Amemiya-Kudo, M, Shimano, H, Hasty, AH, Yahagi, N, Yoshikawa, T, Matsuzaka, T, Okazaki, H, Tamura, Y, Iizuka, Y, Ohashi, K, Osuga, J, Harada, K, Gotoda, T, Sato, R, Kimura, S, Ishibashi, S, Yamada, N

J Lipid Res 2002
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Rome, S, Lecomte, V, Meugnier, E, Rieusset, J, Debard, C, Euthine, V, Vidal, H, Lefai, E

Physiol Genomics 2008
7592729 Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

Bennett, MK, Lopez, JM, Sanchez, HB, Osborne, TF

J Biol Chem 1995
10759542 Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

Xiong, S, Chirala, SS, Wakil, SJ

Proc Natl Acad Sci U S A 2000
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Cho, SY, Park, HW, Lee, SJ, Lee, TR

J Nutr 2007
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Pai, JT, Guryev, O, Brown, MS, Goldstein, JL

J Biol Chem 1998
18682402 Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)

Choi, WI, Jeon, BN, Park, H, Yoo, JY, Kim, YS, Koh, DI, Kim, MH, Kim, YR, Lee, CE, Kim, KS, Osborne, TF, Hur, MW

J Biol Chem 2008
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