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SREBP1A,2 binds the DHCR7 promoter
Stable Identifier
R-HSA-2426155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SREBF1A,2 binds the DHCR7 promoter
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
Literature References
PubMed ID
Title
Journal
Year
18654640
Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
Szekely, AM
,
Weissman, SM
,
Reed, BD
,
Snyder, M
,
Charos, AE
PLoS Genet
2008
Participants
Input
DHCR7 gene [nucleoplasm]
(Homo sapiens)
NF-Y [nucleoplasm]
(Homo sapiens)
SP1 [nucleoplasm]
(Homo sapiens)
SREBP1A,2 dimer [nucleoplasm]
(Homo sapiens)
Output
SREBP1A,2:NF-Y:SP1:DHCR7 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Authored
May, B (2012-07-26)
Reviewed
Liang, G (2012-08-26)
Created
May, B (2012-07-27)
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