Reactome | PDGFA [extracellular region]

PDGFA [extracellular region]

Stable Identifier

R-HSA-2426265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Platelet-derived growth factor subunit A, PDGFA_HUMAN

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating tumorigenic genes (Homo sapiens)
        
        NFE2L2 dependent PDGFA expression (Homo sapiens)
        
        PDGFA [extracellular region] (Homo sapiens)

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
    - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - PDGFA homodimer [extracellular region] (Homo sapiens)
        
        PDGFA [extracellular region] (Homo sapiens)
    - HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
        
        PDGFA homodimer [extracellular region] (Homo sapiens)
        
        PDGFA [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04085 PDGFA

Gene Names

PDGFA, PDGF1

Chain

signal peptide:1-20, propeptide:21-86, chain:87-211

Reference Genes

BioGPS Gene:5154 PDGFA

COSMIC (genes):PDGFA PDGFA

CTD Gene:5154 PDGFA

dbSNP Gene:5154 PDGFA

ENSEMBL:ENSG00000197461 PDGFA

HGNC:8799 PDGFA

KEGG:hsa:5154 PDGFA

Monarch:5154 PDGFA

NCBI Gene:5154 PDGFA

OMIM:173430 PDGFA

UCSC:P04085 PDGFA

Reference Transcript

Participates

as a component of

PDGFA homodimer [extracellular region] (Homo sapiens)

as an output of

NFE2L2 dependent PDGFA expression (Homo sapiens)

Inferred To

Pvf1 [extracellular region] (Drosophila melanogaster)

pvf-1 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001382295.1, XP_054214342.1, XP_047276413.1, NP_002598.4, NP_148983.1

ENSEMBL

ENSP00000346508, ENSP00000383889, ENSG00000197461, ENST00000402802, ENST00000354513

OpenTargets

ENSG00000197461

GeneCards

PDGFA

HPA

ENSG00000197461-PDGFA

ZINC - Substances

PDGFA_HUMAN

ZINC target

P04085

PRO

P04085

Pharos - Targets

P04085

GlyGen

P04085

ZINC - Predictions - Purchasable

PDGFA_HUMAN

PDB

3MJK

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.691	6
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.524	5

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