Reactome | PDGFA [extracellular region]

PDGFA [extracellular region]

Stable Identifier

R-HSA-2426265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Platelet-derived growth factor subunit A, PDGFA_HUMAN

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
    - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - PDGFA homodimer [extracellular region] (Homo sapiens)
        
        PDGFA [extracellular region] (Homo sapiens)
    - HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
        
        PDGFA homodimer [extracellular region] (Homo sapiens)
        
        PDGFA [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04085 PDGFA

Gene Names

PDGFA, PDGF1

Chain

signal peptide:1-20, propeptide:21-86, chain:87-211

Reference Genes

BioGPS Gene:5154 PDGFA

COSMIC (genes):PDGFA PDGFA

CTD Gene:5154 PDGFA

dbSNP Gene:5154 PDGFA

ENSEMBL:ENSG00000197461 PDGFA

HGNC:8799 PDGFA

KEGG Gene (Homo sapiens):5154 PDGFA

Monarch:5154 PDGFA

NCBI Gene:5154 PDGFA

OMIM:173430 PDGFA

UCSC:P04085 PDGFA

Reference Transcript

Other Identifiers

0000840142

1109_s_at

11729062_a_at

11729063_a_at

11750974_a_at

17054243

205463_s_at

216867_s_at

35703_at

4049075

4049082

4049083

4049419

4049421

4049426

4049428

4049430

4049431

5154

8137670

A_33_P3372666

GE59683

GO:0000139

GO:0000165

GO:0001525

GO:0001775

GO:0001942

GO:0002053

GO:0002576

GO:0003674

GO:0005161

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005902

GO:0006464

GO:0006629

GO:0006810

GO:0006950

GO:0007010

GO:0007165

GO:0007267

GO:0007275

GO:0008083

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0009611

GO:0009790

GO:0009887

GO:0009986

GO:0010512

GO:0010544

GO:0014068

GO:0014910

GO:0016020

GO:0016192

GO:0022607

GO:0030031

GO:0030036

GO:0030198

GO:0030335

GO:0031093

GO:0031410

GO:0031954

GO:0032956

GO:0035793

GO:0040011

GO:0042060

GO:0042803

GO:0043226

GO:0043406

GO:0043410

GO:0043588

GO:0046982

GO:0048008

GO:0048146

GO:0048286

GO:0048407

GO:0048646

GO:0048856

GO:0048870

GO:0050730

GO:0050919

GO:0051301

GO:0051781

GO:0051897

GO:0060683

GO:0070374

GO:0070851

GO:1990401

Hs.37040.2.S1_3p_a_at

ILMN_1685982

ILMN_2342695

M19989_cds2_at

PH_hs_0028268

TC07001073.hg

g4505678_3p_at

Participant Of

hasComponent

PDGFA homodimer [extracellular region]

Inferred To

Pdgfa [extracellular region] (Mus musculus)

Pdgfa [extracellular region] (Rattus norvegicus)

PDGFA-1 [extracellular region] (Xenopus tropicalis)

PDGFA [extracellular region] (Canis familiaris)

pvf-1 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002598.4, NP_148983.1

OpenTargets

ENSG00000197461

GeneCards

P04085

ZINC - Substances

PDGFA_HUMAN

HPA

ENSG00000197461-PDGFA

ZINC target

P04085

Ensembl

ENST00000402802, ENSP00000383889, ENST00000354513, ENSP00000346508, ENSG00000197461

PRO

P04085

ZINC - Predictions - Purchasable

PDGFA_HUMAN

PDB

3MJK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16234 PDGFRA	47	PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA D843_846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974) PDGFRA D843_844del [plasma membrane] (R-HSA-9671559) PDGFRA D846V [plasma membrane] (R-HSA-9674306) PDGFRA D842L [plasma membrane] (R-HSA-9674303) PDGFRA V561D [plasma membrane] (R-HSA-9671557) PDGFRA V561A [plasma membrane] (R-HSA-9671968) PDGFRA V536E [plasma membrane] (R-HSA-9671964) PDGFRA V536M [plasma membrane] (R-HSA-9676950) p-11Y PDGFRA D842V [plasma membrane] (R-HSA-9671979) p-11Y PDGFRA D846Y [plasma membrane] (R-HSA-9672009) p-11Y PDGFRA D842del [plasma membrane] (R-HSA-9671998) p-11Y PDGFRA D843_844del [plasma membrane] (R-HSA-9672001) p-11Y PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671991) p-11Y PDGFRA D843_846del [plasma membrane] (R-HSA-9672007) p-11Y PDGFRA D842Y [plasma membrane] (R-HSA-9671982) p-11Y PDGFRA D842_H845del [plasma membrane] (R-HSA-9671989) p-11Y PDGFRA D842_D846del [plasma membrane] (R-HSA-9671986) p-10Y PDGFRA Y849C [plasma membrane] (R-HSA-9671977) p-11Y PDGFRA D843_845del [plasma membrane] (R-HSA-9672003) p-11Y PDGFRA N848K [plasma membrane] (R-HSA-9672015) p-11Y PDGFRA D842L dimer [plasma membrane] (R-HSA-9674313) p-11Y PDGFRA D846V [plasma membrane] (R-HSA-9674316) p-11Y PDGFRA V536E [plasma membrane] (R-HSA-9672018) p-11Y PDGFRA V536M [plasma membrane] (R-HSA-9676956) p-11Y PDGFRA V561D [plasma membrane] (R-HSA-9672025) p-11Y PDGFRA V561A [plasma membrane] (R-HSA-9672021) PDGFRA [plasma membrane] (R-HSA-186794) p-11Y-PDGFRA [plasma membrane] (R-HSA-186806)	0.704	6

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