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Formation of laminin networks
Stable Identifier
R-HSA-2426676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Laminin interactions (Homo sapiens)
Formation of laminin networks (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The principal structural elements of basement membrane are laminin (LM) and collagen IV. These form distinct networks that become noncovalently interconnected by nidogen and perlecan, both of which are able to form irregular polymers (Breitkreutz et al. 2013). LM polymeric networks can self-assemble even in the absence of other basement membrane components (Yurchenco et al. 1992) suggesting a key developmental role. Polymerization in vivo occurs at the cell surface, to which LMs are anchored through direct or indirect interactions with cellular receptors, dystroglycan or integrins, and possibly other receptors (Hohenester & Yurchenco 2013). Receptor-engaged LM exceeds the critical concentration for self-assembly (Colognato & Yurchenco 2000).
The three short arms of the cross-shaped LM molecule form the nodes in the polymeric network, with a strict requirement for one each of alpha, beta and gamma arms (Hohenester & Yurchenco 2013). A surface loop, strictly conserved in the LN domains of all alpha chains, is required for stable ternary association with the beta and gamma short arms (Hussain et al. 2011).
Participants
Input
Laminins [extracellular region]
(Homo sapiens)
Output
Laminin network [extracellular region]
(Homo sapiens)
Participates
as an event of
Laminin interactions (Homo sapiens)
Inferred From
Formation of laminin networks (Mus musculus)
Authored
Jupe, S (2012-08-08)
Reviewed
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2012-08-08)
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