Reactome | IGF1R signaling cascade

IGF1R signaling cascade

Stable Identifier

R-HSA-2428924

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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After autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activity (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, and Siddle et al. 2012). IRS1/2/4 can bind both PI3K (via the p85 subunit of PI3K) and the GRB2:SOS complex. PI3K activates PKB (AKT, AKT1) signaling. GRB:SOS stimulates RAS to exchange GDP for GTP leading to activation of RAF and MAPK.

Literature References

PubMed ID	Title	Journal	Year
22649417	Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Siddle, K	Front Endocrinol (Lausanne)	2012
20098959	Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain Longo, VD, Parrella, E	ScientificWorldJournal	2010
20975071	Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer Maki, RG	J. Clin. Oncol.	2010
17598937	Biological & physiological aspects of action of insulin-like growth factor peptide family Knezević, J, Matijević, T, Pavelić, J	Indian J. Med. Res.	2007
21042815	The IGF system Ghigo, E, Annunziata, M, Granata, R	Acta Diabetol	2011
18927274	The type 1 insulin-like growth factor receptor pathway Chitnis, MM, Macaulay, VM, Protheroe, AS, Pollak, M, Yuen, JS	Clin. Cancer Res.	2008