Reactome | IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4

IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4

Stable Identifier

R-HSA-2428926

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4

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Phosphorylated IGF1R phosphorylates IRS1 (Siemeister et al. 1995, Xu et al. 1995, Takahashi et al. 1997, Rakatzi et al. 2006), IRS2 (Kim et al. 1998, Kim et al. 2004), and IRS4 (Fantin et al.1998, Karas et al. 2001, Cuevas et al. 2007) on numerous tyrosine residues. IRS4 is phosphorylated by IGF1R in HEK cells but not in primary muscle cells (Fantin et al. 1998, Schreyer et al. 2003). The phosphotyrosine resideus create binding sites for downstream effectors such as GRB2:SOS and PI3K.

Literature References

PubMed ID	Title	Journal	Year
17408801	Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation Cuevas, EP, Román, ID, Ramirez Rubio, S, Guijarro, LG, Escribano, O, Chiloeches, A, Fernández-Moreno, MD	J. Hepatol.	2007
7876259	Recombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinase al-Hasani, H, Krone, W, Müller-Wieland, D, Streicher, R, Kellner, S, Klein, HW, Siemeister, G	J. Biol. Chem.	1995
9832424	Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells White, MF, Feldman, EL, Leventhal, PS, Kim, B	Endocrinology	1998
9003010	Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts Yazaki, Y, Kadowaki, T, Takahashi, Y, Tobe, K, Fukushima, Y, Kadowaki, H, Katsumata, D, Akanuma, Y	Endocrinology	1997
14712218	Insulin-like growth factor-I signaling in human neuroblastoma cells van Golen, CM, Feldman, EL, Kim, B	Oncogene	2004
11316748	The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II Zick, Y, Karas, M, Koval, AP, LeRoith, D	Endocrinology	2001
9553137	Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW	J. Biol. Chem.	1998
16754202	Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors Rakatzi, I, Siddle, K, Gromke, T, Eckel, J, Stosik, M	Arch. Physiol. Biochem.	2006
12639902	Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor Rakatzi, I, Ledwig, D, Klöting, I, Schreyer, S, Eckel, J	Endocrinology	2003
8530377	Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains Bird, VG, Xu, B, Miller, WT	J. Biol. Chem.	1995
9852124	Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling Feldman, EL, Cheng, HL, Margolis, B, Kim, B	J. Biol. Chem.	1998