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IRS2 [plasma membrane]
Stable Identifier
R-HSA-2428927
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Insulin receptor substrate-2, IRS-2
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)
IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Homo sapiens)
IRS2 [plasma membrane] (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)
IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] (Homo sapiens)
IRS1,2,4 [plasma membrane] (Homo sapiens)
IRS2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4H2 IRS2
Gene Names
IRS2
Chain
chain:1-1338
Reference Genes
BioGPS Gene:8660 IRS2
COSMIC (genes):IRS2 IRS2
CTD Gene:8660 IRS2
dbSNP Gene:8660 IRS2
ENSEMBL:ENSG00000185950 IRS2
HGNC:6126 IRS2
KEGG:hsa:8660 IRS2
Monarch:8660 IRS2
NCBI Gene:8660 IRS2
OMIM:600797 IRS2
UCSC:Q9Y4H2 IRS2
Reference Transcript
RefSeq:NM_003749.2 IRS2
Other Identifiers
11718012_at
11718013_at
16780917
209184_PM_s_at
209184_s_at
209185_PM_s_at
209185_s_at
3525236
3525237
3525238
3525239
3525240
3525241
3525242
3525243
3525259
3525260
3525261
3525262
3525263
3525264
3525265
3525266
3525267
3525268
3525269
3525270
3525271
3525272
3525273
3525274
3525275
3525276
40180_at
48795_at
56338_at
7972745
8660
A_24_P154037
A_24_P207003
GO:0002053
GO:0002903
GO:0005068
GO:0005158
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006006
GO:0007165
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0016477
GO:0019216
GO:0019901
GO:0019903
GO:0019904
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0033673
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048856
GO:0048870
GO:0051897
GO:0055088
GO:0060090
GO:0071333
GO:0071889
GO:0098772
GO:0141038
GO:1901653
GO:1904692
HMNXSV003028001
Hs.143648.0.S2_3p_a_at
ILMN_2083469
PH_hs_0008458
TC13000871.hg
g4511968_3p_a_at
Participates
as a component of
IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Homo sapiens)
as a member of
IRS1,2,4 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IRS2 [cytosol]
p-Y-IRS2 [cytosol]
p-Y-IRS2 [plasma membrane]
Inferred To
IRS2 [plasma membrane]
(Bos taurus)
IRS2 [plasma membrane]
(Canis familiaris)
IRS2 [plasma membrane]
(Sus scrofa)
LOC100498409 [plasma membrane]
(Xenopus tropicalis)
Irs2 [plasma membrane]
(Mus musculus)
Irs2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_003740.2
ENSEMBL
ENSP00000365016
,
ENST00000375856
OpenTargets
ENSG00000185950
HPA
ENSG00000185950-IRS2
PRO
Q9Y4H2
Pharos - Targets
Q9Y4H2
GlyGen
Q9Y4H2
PDB
3FQX
,
3FQW
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.862
9
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.826
7
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.816
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.802
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.763
6
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.688
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.589
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.569
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
4
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.527
4
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.527
2
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