IRS-related events triggered by IGF1R

Stable Identifier
R-HSA-2428928
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Pathway
Species
Homo sapiens
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The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IRS1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.

Literature References
PubMed ID Title Journal Year
20098959 Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain

Parrella, E, Longo, VD

ScientificWorldJournal 2010
22649417 Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances

Siddle, K

Front Endocrinol (Lausanne) 2012
20975071 Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

Maki, RG

J. Clin. Oncol. 2010
17598937 Biological & physiological aspects of action of insulin-like growth factor peptide family

Pavelić, J, Matijević, T, Knezević, J

Indian J. Med. Res. 2007
21042815 The IGF system

Annunziata, M, Granata, R, Ghigo, E

Acta Diabetol 2011
18927274 The type 1 insulin-like growth factor receptor pathway

Chitnis, MM, Yuen, JS, Protheroe, AS, Pollak, M, Macaulay, VM

Clin. Cancer Res. 2008
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