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APOE [early endosome]
Stable Identifier
R-HSA-2429687
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome
Synonyms
apoE, apolipoprotein E
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LDLR transports extracellular CR:atREs to cytosol (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
NREH hydrolyses atREs to atROL and FAs (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LDLR transports extracellular CR:atREs to cytosol (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
NREH hydrolyses atREs to atROL and FAs (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
CR:atREs [early endosome] (Homo sapiens)
CR [early endosome] (Homo sapiens)
APOE [early endosome] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02649 APOE
Gene Names
APOE
Chain
signal peptide:1-18, chain:19-317
Reference Genes
BioGPS Gene:348 APOE
COSMIC (genes):APOE APOE
CTD Gene:348 APOE
dbSNP Gene:348 APOE
ENSEMBL:ENSG00000130203 APOE
HGNC:613 APOE
KEGG Gene (Homo sapiens):348 APOE
Monarch:348 APOE
NCBI Gene:348 APOE
OMIM:107741 APOE
UCSC:P02649 APOE
Reference Transcript
RefSeq:NM_000041.3 APOE
RefSeq:NM_001302689.1 APOE
RefSeq:NM_001302688.1 APOE
RefSeq:NM_001302690.1 APOE
RefSeq:NM_001302691.1 APOE
Other Identifiers
0001090075
11744068_x_at
16863115
1B68
1BZ4
1EA8
1GS9
1H7I
1LE2
1LE4
1LPE
1NFN
1NFO
1OEF
1OEG
1OR2
1OR3
203381_s_at
203382_s_at
212884_x_at
2KC3
2KNY
2L7B
348
3835880
3835883
3835884
3835886
3835887
3835888
3835889
3835890
608_at
65539
68768
69921
6NCN
6NCO
8029530
8363
A0A0S2Z3D5
A_14_P133396
A_23_P164650
A_33_P3223592
AAB59397
AAB59518
AAB59546
AAD02505
AAG27089
AAH03557
AB035149
ACN81314
AF050154
AF261279
AK314898
ALQ33368
APOE
APOE-201
BAA96080
BAG37412
BC003557
CAB008363
CAB069921
CCDS12647
E7ERP7
E9PEV4
ENSG00000130203
ENSP00000252486
ENST00000252486
ENST00000252486.8
EntrezGene:348
EntrezGene:APOE
FJ525876
g4557324_3p_a_at
GE80881
GO:0000302
GO:0000902
GO:0001523
GO:0001540
GO:0001937
GO:0002021
GO:0002376
GO:0003013
GO:0003674
GO:0005102
GO:0005198
GO:0005319
GO:0005515
GO:0005543
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005788
GO:0005794
GO:0005886
GO:0006357
GO:0006464
GO:0006629
GO:0006641
GO:0006707
GO:0006810
GO:0006869
GO:0006874
GO:0006898
GO:0006950
GO:0006979
GO:0007010
GO:0007165
GO:0007186
GO:0007263
GO:0007267
GO:0007271
GO:0007616
GO:0008092
GO:0008150
GO:0008201
GO:0008202
GO:0008203
GO:0008219
GO:0008283
GO:0008289
GO:0009056
GO:0009058
GO:0010468
GO:0010544
GO:0010596
GO:0010629
GO:0010873
GO:0010875
GO:0010877
GO:0010976
GO:0010977
GO:0015031
GO:0015909
GO:0016020
GO:0016192
GO:0016209
GO:0017038
GO:0019068
GO:0019934
GO:0022607
GO:0030154
GO:0030195
GO:0030234
GO:0030425
GO:0030516
GO:0030669
GO:0031012
GO:0031175
GO:0031410
GO:0032269
GO:0032489
GO:0032805
GO:0032991
GO:0033344
GO:0033700
GO:0034361
GO:0034362
GO:0034363
GO:0034364
GO:0034365
GO:0034371
GO:0034372
GO:0034374
GO:0034375
GO:0034378
GO:0034380
GO:0034382
GO:0034384
GO:0034447
GO:0034641
GO:0035641
GO:0040007
GO:0040011
GO:0042157
GO:0042158
GO:0042159
GO:0042311
GO:0042592
GO:0042627
GO:0042632
GO:0042802
GO:0042803
GO:0042981
GO:0042982
GO:0043025
GO:0043083
GO:0043085
GO:0043167
GO:0043226
GO:0043254
GO:0043395
GO:0043407
GO:0043524
GO:0043537
GO:0043687
GO:0043691
GO:0044267
GO:0044281
GO:0044403
GO:0044794
GO:0044877
GO:0045088
GO:0045541
GO:0045807
GO:0045893
GO:0046889
GO:0046907
GO:0046911
GO:0046983
GO:0048156
GO:0048168
GO:0048844
GO:0048856
GO:0048870
GO:0050709
GO:0050728
GO:0050750
GO:0050807
GO:0050877
GO:0051000
GO:0051044
GO:0051246
GO:0051651
GO:0055088
GO:0055089
GO:0060228
GO:0060999
GO:0061024
GO:0061136
GO:0061771
GO:0062023
GO:0065003
GO:0070062
GO:0070326
GO:0070328
GO:0070374
GO:0071682
GO:0071813
GO:0071830
GO:0071831
GO:0072358
GO:0072562
GO:0090090
GO:0090181
GO:0090209
GO:0097006
GO:0097113
GO:0097114
GO:0098869
GO:0098978
GO:0120020
GO:1900221
GO:1900223
GO:1900272
GO:1901215
GO:1901628
GO:1901630
GO:1902430
GO:1902952
GO:1902991
GO:1902995
GO:1903002
GO:1903561
GO:1905855
GO:1905860
GO:1905890
GO:1905906
GO:1905907
GO:1905908
GO:1990777
GO:2000822
H0Y7L5
HGNC:613
HPA065539
HPA068768
Hs.169401.0.S1_3p_a_at
ILMN_1740938
IPR000074
K00396
KU177910
M10065
M12529
M12529_at
MIM:104310
MIM:107741
MIM:269600
MIM:603075
MIM:606889
MIM:611771
MIM:617347
NM_000041
NM_001302689
NM_001302690
NM_001302691
NP_000032
NP_001289618
NP_001289619
NP_001289620
PF01442
PH_hs_0022287
TC19000633.hg
UPI0000044948
Participant Of
output
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs
hasComponent
CR [early endosome]
CR:atREs:HSPG:apoE [early endosome]
Other forms of this molecule
APOE [endocytic vesicle lumen]
APOE [endosome lumen]
APOE [endosome membrane]
APOE [clathrin-coated endocytic vesicle membrane]
APOE [plasma membrane]
p-APOE [endoplasmic reticulum lumen]
APOE [extracellular region]
APOE [endoplasmic reticulum lumen]
Inferred To
Ghost homologue of APOE [early endosome] (Bos taurus)
APOE [early endosome] (Danio rerio)
APOE [early endosome] (Mus musculus)
APOE [early endosome] (Rattus norvegicus)
Cross References
RefSeq
NP_000032.1
,
NP_001289620.1
,
NP_001289619.1
,
NP_001289617.1
,
NP_001289618.1
OpenTargets
ENSG00000130203
GeneCards
P02649
PRO
P02649
Orphanet
15940
HMDB Protein
HMDBP01986
PDB
2KNY
,
1NFO
,
2KC3
,
1NFN
,
1LPE
,
1EA8
,
1OR3
,
1LE4
,
1B68
,
2L7B
,
1OR2
,
6NCN
,
1BZ4
,
1GS9
,
6NCO
,
1OEG
,
1H7I
,
1LE2
,
1OEF
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07954 LRP1
3
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
LRP1 [plasma membrane]
(R-HSA-2424272)
0.784
23
UniProt:P05067-PRO_0000000093 APP
0.75
4
UniProt:P01130 LDLR
4
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.71
4
UniProt:P00738 HP
7
7xHC-HP(19-160) [endocytic vesicle lumen]
(R-HSA-2230994)
5xHC-HP(162-406) [endocytic vesicle lumen]
(R-HSA-2230973)
5xHC-HP(162-406) [extracellular region]
(R-HSA-2168875)
7xHC-HP(19-160) [extracellular region]
(R-HSA-2168848)
HP [specific granule lumen]
(R-HSA-6799622)
HP [extracellular region]
(R-HSA-6799677)
HP [tertiary granule lumen]
(R-HSA-6800879)
0.675
7
ChEBI:28304 HEPARIN
0.645
5
UniProt:P02649 APOE
9
APOE [endosome lumen]
(R-HSA-174804)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE [early endosome]
(R-HSA-2429687)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [extracellular region]
(R-HSA-174646)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
0.641
9
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.602
4
UniProt:O75069 TMCC2
0.593
5
ChEBI:241349 DIMYRISTOYLPHOSPHATIDYL CHOLINE
0.59
3
UniProt:P27958-PRO_0000037570
0.537
4
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.524
4
UniProt:P50502 ST13
1
ST13 [cytosol]
(R-HSA-5255410)
0.482
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.482
3
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.482
3
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