p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D

Stable Identifier
R-HSA-2430552
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARPP19 and ENSA, activated by MASTL (GWL) mediated phosphorylation, bind and inhibit PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D phosphatase activity allows mitotis entry and mainetance by preventing dephosphorylation of CDK1 mitotic targets (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).

Literature References
PubMed ID Title Journal Year
21164014 The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Gharbi-Ayachi, A, Labbe, JC, Burgess, A, Vigneron, S, Strub, JM, Brioudes, E, Van-Dorsselaer, A, Castro, A, Lorca, T

Science 2010
21164013 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

Mochida, S, Maslen, SL, Skehel, M, Hunt, T

Science 2010
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