Reactome | RBP4(19-201) [extracellular region]

RBP4(19-201) [extracellular region]

Stable Identifier

R-HSA-2453675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

RBP4, Retinol-binding protein 4, RET4_HUMAN, RBP

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of the neuronal system (Homo sapiens)
  - Diseases associated with visual transduction (Homo sapiens)
    - Retinoid cycle disease events (Homo sapiens)
      - Defective STRA6 does not transport atROL (Homo sapiens)
        
        TTR:RBP4:atROL:STRA6 mutants [plasma membrane] (Homo sapiens)
        
        TTR:RBP4:atROL [extracellular region] (Homo sapiens)
        
        RBP4:atROL [extracellular region] (Homo sapiens)
        
        RBP4(19-201) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02753 RBP4

Gene Names

RBP4, PRO2222

Chain

signal peptide:1-18, chain:19-201, chain:19-200, chain:19-199, chain:19-197, chain:19-194

Reference Genes

BioGPS Gene:5950 RBP4

COSMIC (genes):RBP4 RBP4

CTD Gene:5950 RBP4

dbSNP Gene:5950 RBP4

ENSEMBL:ENSG00000138207 RBP4

HGNC:9922 RBP4

KEGG Gene (Homo sapiens):5950 RBP4

Monarch:5950 RBP4

NCBI Gene:5950 RBP4

OMIM:180250 RBP4

UCSC:P02753 RBP4

Reference Transcript

Other Identifiers

0000540239

11718132_at

16716659

219140_s_at

32552_at

3300753

3300754

3300755

3300756

3300761

3300769

3300770

3300774

3300775

3300776

3300777

3300778

5950

7935116

A_23_P75283

GE58418

GO:0000003

GO:0001523

GO:0001654

GO:0002376

GO:0003674

GO:0005501

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006094

GO:0006629

GO:0006810

GO:0007267

GO:0007507

GO:0007601

GO:0008150

GO:0008283

GO:0008289

GO:0009058

GO:0009790

GO:0015031

GO:0016918

GO:0019841

GO:0022857

GO:0030277

GO:0030324

GO:0032024

GO:0032526

GO:0032991

GO:0034632

GO:0034633

GO:0040007

GO:0042572

GO:0042592

GO:0042593

GO:0043226

GO:0044281

GO:0044877

GO:0045471

GO:0048562

GO:0048646

GO:0048706

GO:0048738

GO:0048807

GO:0048856

GO:0050877

GO:0050896

GO:0051024

GO:0060044

GO:0060059

GO:0060065

GO:0060068

GO:0060157

GO:0060347

GO:0070062

ILMN_1814719

TC10001537.hg

X00129_at

g8400727_3p_a_at

Participant Of

input

RBP4 binds atROL

hasComponent

Other forms of this molecule

RBP4 G75D [extracellular region]

RBP4 I41N [extracellular region]

Inferred To

rbp4 [extracellular region] (Danio rerio)

rbp4 [extracellular region] (Xenopus tropicalis)

Rbp4 [extracellular region] (Mus musculus)

Rbp4 [extracellular region] (Rattus norvegicus)

RBP4 [extracellular region] (Canis familiaris)

RBP4 [extracellular region] (Gallus gallus)

RBP4 [extracellular region] (Sus scrofa)

lpr-2 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001310446.1, NP_001310447.1, NP_006735.2

ZINC - World Drugs

RET4_HUMAN

OpenTargets

ENSG00000138207

ZINC - FDA approved

RET4_HUMAN

ZINC - Substances

RET4_HUMAN

ZINC target

P02753

ZINC - Biogenic

RET4_HUMAN

PRO

P02753

PDB

5NU7, 1JYD, 1QAB, 2WQ9, 5NU6, 4O9S, 6QBA, 3BSZ, 5NUB, 1JYJ, 5NUA, 2WQA, 1RBP, 5NU9, 4PSQ, 1BRP, 5NU2, 5NU8, 1BRQ, 2WR6, 1RLB, 5NTY, 3FMZ

ZINC - Investigational

RET4_HUMAN

ZINC - Metabolites

RET4_HUMAN

GeneCards

P02753

HPA

ENSG00000138207-RBP4

Ensembl

ENST00000371464, ENSP00000360519, ENST00000371467, ENSG00000138207, ENSP00000360522

ZINC - Predictions - Purchasable

RET4_HUMAN

Orphanet

22181

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.667	4
UniProt:O55245 TTHY			0.558	2