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RBP4(19-201) [extracellular region]
Stable Identifier
R-HSA-2453675
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
RBP4, Retinol-binding protein 4, RET4_HUMAN, RBP
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of the neuronal system (Homo sapiens)
Diseases associated with visual transduction (Homo sapiens)
Retinoid cycle disease events (Homo sapiens)
Defective STRA6 does not transport atROL (Homo sapiens)
TTR:RBP4:atROL:STRA6 mutants [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
RBP4 binds atROL (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
RBP4:atROL binds TTR (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
RBP4 binds atROL (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
RBP4:atROL binds TTR (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)
TTR:RBP4:STRA6 [plasma membrane] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
TTR:RBP4:atROL:STRA6 [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
TTR:RBP4:atROL:STRA6 [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
RBP4:atROL [extracellular region] (Homo sapiens)
RBP4(19-201) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02753 RBP4
Gene Names
RBP4, PRO2222
Chain
signal peptide:1-18, chain:19-201, chain:19-200, chain:19-199, chain:19-197, chain:19-194
Reference Genes
BioGPS Gene:5950 RBP4
COSMIC (genes):RBP4 RBP4
CTD Gene:5950 RBP4
dbSNP Gene:5950 RBP4
ENSEMBL:ENSG00000138207 RBP4
HGNC:9922 RBP4
KEGG Gene (Homo sapiens):5950 RBP4
Monarch:5950 RBP4
NCBI Gene:5950 RBP4
OMIM:180250 RBP4
UCSC:P02753 RBP4
Reference Transcript
RefSeq:NM_001323517.1 RBP4
RefSeq:NM_006744.3 RBP4
RefSeq:NM_001323518.1 RBP4
Other Identifiers
0000540239
11718132_at
16716659
219140_s_at
32552_at
3300753
3300754
3300755
3300756
3300761
3300769
3300770
3300774
3300775
3300776
3300777
3300778
5950
7935116
A_23_P75283
GE58418
GO:0000003
GO:0001523
GO:0001654
GO:0002376
GO:0003674
GO:0005501
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005975
GO:0006094
GO:0006629
GO:0006810
GO:0007267
GO:0007507
GO:0007601
GO:0008150
GO:0008283
GO:0008289
GO:0009058
GO:0009790
GO:0015031
GO:0016918
GO:0019841
GO:0022857
GO:0030277
GO:0030324
GO:0032024
GO:0032526
GO:0032991
GO:0034632
GO:0034633
GO:0040007
GO:0042572
GO:0042592
GO:0042593
GO:0043226
GO:0044281
GO:0044877
GO:0045471
GO:0048562
GO:0048646
GO:0048706
GO:0048738
GO:0048807
GO:0048856
GO:0050877
GO:0050896
GO:0051024
GO:0060044
GO:0060059
GO:0060065
GO:0060068
GO:0060157
GO:0060347
GO:0070062
ILMN_1814719
TC10001537.hg
X00129_at
g8400727_3p_a_at
Participant Of
input
RBP4 binds atROL
hasComponent
RBP4:atROL [extracellular region]
TTR:RBP4:STRA6 [plasma membrane]
Other forms of this molecule
RBP4 G75D [extracellular region]
RBP4 I41N [extracellular region]
Inferred To
rbp4 [extracellular region] (Danio rerio)
rbp4 [extracellular region] (Xenopus tropicalis)
Rbp4 [extracellular region] (Mus musculus)
Rbp4 [extracellular region] (Rattus norvegicus)
RBP4 [extracellular region] (Canis familiaris)
RBP4 [extracellular region] (Gallus gallus)
RBP4 [extracellular region] (Sus scrofa)
lpr-2 [extracellular region] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001310446.1
,
NP_001310447.1
,
NP_006735.2
ZINC - World Drugs
RET4_HUMAN
OpenTargets
ENSG00000138207
ZINC - FDA approved
RET4_HUMAN
ZINC - Substances
RET4_HUMAN
ZINC target
P02753
ZINC - Biogenic
RET4_HUMAN
PRO
P02753
PDB
5NU7
,
1JYD
,
1QAB
,
2WQ9
,
5NU6
,
4O9S
,
6QBA
,
3BSZ
,
5NUB
,
1JYJ
,
5NUA
,
2WQA
,
1RBP
,
5NU9
,
4PSQ
,
1BRP
,
5NU2
,
5NU8
,
1BRQ
,
2WR6
,
1RLB
,
5NTY
,
3FMZ
ZINC - Investigational
RET4_HUMAN
ZINC - Metabolites
RET4_HUMAN
GeneCards
P02753
HPA
ENSG00000138207-RBP4
Ensembl
ENST00000371464
,
ENSP00000360519
,
ENST00000371467
,
ENSG00000138207
,
ENSP00000360522
ZINC - Predictions - Purchasable
RET4_HUMAN
Orphanet
22181
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.667
4
UniProt:O55245 TTHY
0.558
2
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