LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier
R-HSA-2453855
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
LRAT esterifies all-trans-retinol in RPE
Locations in the PathwayBrowser
Summation

Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) to form all-trans-retinyl esters (atREs). atREs are stored in lipid droplet form called retinosomes (Imanishi et al. 2004). Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999). LRAT is an important enzyme required for the clearance of atROL as it drives the uptake of atROL from the bloodstream through the receptor STRA6 (Kawaguchi et al. 2011) and clearance of atROL from rod outer segments (ROS). In addition, the esterified form of atROL serves as substrate for RPE65.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
O-palmitoyltransferase activity of LRAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events