LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier
R-HSA-2453855
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane, lipid droplet, plasma membrane
Synonyms
LRAT esterifies all-trans-retinol in RPE
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LRAT esterifies RBP1:atROL and FACYLs to atREs
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Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) to form all-trans-retinyl esters (atREs). atREs are stored in lipid droplet form called retinosomes (Imanishi et al. 2004). Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999). LRAT is an important enzyme required for the clearance of atROL as it drives the uptake of atROL from the bloodstream through the receptor STRA6 (Kawaguchi et al. 2011) and clearance of atROL from rod outer segments (ROS). In addition, the esterified form of atROL serves as substrate for RPE65.

Literature References
PubMed ID Title Journal Year
9920938 Molecular and biochemical characterization of lecithin retinol acyltransferase.

Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D

J Biol Chem 1999
15314061 Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies

Imanishi, Y, Gerke, V, Palczewski, K

J. Cell Biol. 2004
21774515 Receptor-mediated cellular uptake mechanism that couples to intracellular storage

Kawaguchi, R, Yu, J, Ter-Stepanian, M, Zhong, M, Cheng, G, Yuan, Q, Jin, M, Travis, GH, Ong, D, Sun, H

ACS Chem. Biol. 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
O-palmitoyltransferase activity of LRAT [endoplasmic reticulum membrane]
Physical Entity
LRAT [endoplasmic reticulum membrane]
Activity
O-palmitoyltransferase activity (0016416)
Orthologous Events
LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Taeniopygia guttata)
LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)
Authored
Jassal, B  (2012-08-17)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-08-17)