Reactome | LRAT esterifies RBP1:atROL and FACYLs to atREs

LRAT esterifies RBP1:atROL and FACYLs to atREs

Stable Identifier

R-HSA-2453855

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane, endoplasmic reticulum membrane, lipid droplet, cytosol

Synonyms

LRAT esterifies all-trans-retinol in RPE

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
        
        LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)

Summation

Lecithin retinol acyltransferase (LRAT) mediates the esterification of all-trans-retinol (atROL) to form all-trans-retinyl esters (atREs). atREs are stored in lipid droplet form called retinosomes (Imanishi et al. 2004). Cellular retinol-binding protein 1 (RBP1) is an effective donor of atROL for LRAT (Ruiz et al. 1999). LRAT is an important enzyme required for the clearance of atROL as it drives the uptake of atROL from the bloodstream through the receptor STRA6 (Kawaguchi et al. 2011) and clearance of atROL from rod outer segments (ROS). In addition, the esterified form of atROL serves as substrate for RPE65.

Literature References

PubMed ID	Title	Journal	Year
9920938	Molecular and biochemical characterization of lecithin retinol acyltransferase. Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D	J Biol Chem	1999
15314061	Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies Imanishi, Y, Gerke, V, Palczewski, K	J. Cell Biol.	2004
21774515	Receptor-mediated cellular uptake mechanism that couples to intracellular storage Kawaguchi, R, Yu, J, Ter-Stepanian, M, Zhong, M, Cheng, G, Yuan, Q, Jin, M, Travis, GH, Ong, D, Sun, H	ACS Chem. Biol.	2011