The canonical retinoid cycle in rods (twilight vision)

Stable Identifier
R-HSA-2453902
DOI
10.3180/REACT_160156.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The canonical retinoid cycle in rods (twilight vision)
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The retinoid cycle (also referred to as the visual cycle) is the process by which the visual chromophore 11-cis-retinal (11cRAL) is released from light-activated opsins in the form all-trans-retinal and isomerized back to its 11-cis isomer ready for another photoisomerization reaction. This process involves oxidation, reduction and isomerization reactions and take place in the retinal pigment epithelium (RPE) and photoreceptor segments of the eye (von Lintig 2012, Blomhoff & Blomhoff 2006, von Lintig et al. 2010, D'Ambrosio et al. 2011). This section describes the retinoid cycle in rods during dark/twilight conditions.
Literature References
PubMed ID Title Journal Year
21350678 Vitamin A metabolism: an update

Clugston, RD, Blaner, WS, D'Ambrosio, DN

Nutrients 2011
20188572 The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

Kiser, PD, Golczak, M, von Lintig, J, Palczewski, K

Trends Biochem. Sci. 2010
16688755 Overview of retinoid metabolism and function

Blomhoff, HK, Blomhoff, R

J. Neurobiol. 2006
22074927 Metabolism of carotenoids and retinoids related to vision

von Lintig, J

J. Biol. Chem. 2012
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Event Information
Go Biological Process
retinoid metabolic process (0001523)
Orthologous Events
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
The canonical retinoid cycle in rods (twilight vision) (Dictyostelium discoideum)
The canonical retinoid cycle in rods (twilight vision) (Drosophila melanogaster)
The canonical retinoid cycle in rods (twilight vision) (Gallus gallus)
The canonical retinoid cycle in rods (twilight vision) (Mus musculus)
The canonical retinoid cycle in rods (twilight vision) (Plasmodium falciparum)
The canonical retinoid cycle in rods (twilight vision) (Rattus norvegicus)
The canonical retinoid cycle in rods (twilight vision) (Sus scrofa)
The canonical retinoid cycle in rods (twilight vision) (Xenopus tropicalis)
Authored
Jassal, B  (2012-08-17)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-08-17)
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