RDH5 oxidises 11cROL to 11cRAL

Stable Identifier
R-HSA-2454081
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
RDH5 oxidises 11-cis-retinol to 11-cis-retinal
Locations in the PathwayBrowser
Summation

Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinol dehydrogenase activity of RDH5(1-318)-like Proteins [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events