RDH5 oxidises 11cROL to 11cRAL

Stable Identifier
R-HSA-2454081
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
RDH5 oxidises 11-cis-retinol to 11-cis-retinal
Locations in the PathwayBrowser
Summation

Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.

Literature References
PubMed ID Title Journal Year
10617778 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus

Gonzalez-Fernandez, F, Kurz, D, Bao, Y, Newman, S, Conway, BP, Young, JE, Han, DP, Khani, SC

Mol. Vis. 1999
8884265 Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene

Simon, A, Lagercrantz, J, Bajalica-Lagercrantz, S, Eriksson, U

Genomics 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinol dehydrogenase activity of RDH5(1-318)-like Proteins [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed