Reactome | Allergen dependent IgE bound FCERI aggregation

Allergen dependent IgE bound FCERI aggregation

Stable Identifier

R-HSA-2454192

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Allergen dependent IgE bound FCERI aggregation

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FCERI is primarily expressed on mast cells and basophils as a tetrameric complex comprising an IgE-binding alpha subunit, a signal amplifying membrane-tetraspanning beta subunit, and a disulfide-linked gamma chain dimer that provides the receptor its signaling competence (Blank & Rivera 2004). In the absence of an antigen or allergen, FCERI receptor binds to monomeric IgE antibodies, and thus the receptor adopts the antigenic specificity of the prevalent IgE repertoire (Garman et al. 2000). Mast cell activation is initiated when multivalent antigen crosslinks the IgE bound to the high-affinity FCERI, thereby aggregating FCERI (Siraganian 2003). Antigen driven aggregation of FCERI then elicits intracellular signals that result in mast cell exocytosis.

Literature References

PubMed ID	Title	Journal	Year
14630197	Mast cell signal transduction from the high-affinity IgE receptor Siraganian, RP	Curr. Opin. Immunol.	2003
17498065	Insights into immunoglobulin E receptor signaling from structurally defined ligands Holowka, D, Sil, D, Torigoe, C, Baird, B	Immunol. Rev.	2007
10917520	Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha Garman, SC, Wurzburg, BA, Tarchevskaya, SS, Kinet, JP, Jardetzky, TS	Nature	2000