Phosphorylation of SYK

Stable Identifier
R-HSA-2454239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).

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Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Clustered p:LYN:p-FCERI:IgE:allergin:SYK [plasma membrane]
Physical Entity
Activity
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Created