Recruitment of SYK to p-FCERI gamma subunit

Stable Identifier
R-HSA-2454240
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine phosphorylated ITAM in FCERI gamma subunit serves as docking site for SYK (spleen tyrosine kinases), whereas the beta-subunit ITAM has an extra tyrosine and is shorter than canonical ITAM which makes it unfit to bind SYK. Association of SYK to FCERI gamma-subunit disrupts the COOH-terminal-SH2 interdomain interaction of SYK causing a conformational change opening the molecule leading to its activation (Siraganian et al. 2010, de Castro et al. 2010).

Literature References
PubMed ID Title Journal Year
8910399 Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor

Kimura, T, Kihara, H, Bhattacharyya, S, Sakamoto, H, Appella, E, Siraganian, RP

J. Biol. Chem. 1996
7528327 Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI

Shiue, L, Green, J, Green, OM, Karas, JL, Morgenstern, JP, Ram, MK, Taylor, MK, Zoller, MJ, Zydowsky, LD, Bolen, JB

Mol. Cell. Biol. 1995
8071371 Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor

Kihara, H, Siraganian, RP

J. Biol. Chem. 1994
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