Reactome | Recruitment of SYK to p-FCERI gamma subunit

Recruitment of SYK to p-FCERI gamma subunit

Stable Identifier

R-HSA-2454240

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Recruitment of SYK to p-FCERI gamma subunit

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Tyrosine phosphorylated ITAM in FCERI gamma subunit serves as docking site for SYK (spleen tyrosine kinases), whereas the beta-subunit ITAM has an extra tyrosine and is shorter than canonical ITAM which makes it unfit to bind SYK. Association of SYK to FCERI gamma-subunit disrupts the COOH-terminal-SH2 interdomain interaction of SYK causing a conformational change opening the molecule leading to its activation (Siraganian et al. 2010, de Castro et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
7528327	Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI Shiue, L, Green, J, Green, OM, Karas, JL, Morgenstern, JP, Ram, MK, Taylor, MK, Zoller, MJ, Zydowsky, LD, Bolen, JB	Mol. Cell. Biol.	1995
8910399	Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor Kimura, T, Kihara, H, Bhattacharyya, S, Sakamoto, H, Appella, E, Siraganian, RP	J. Biol. Chem.	1996
8071371	Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor Kihara, H, Siraganian, RP	J. Biol. Chem.	1994