atRAL(membrane) diffuses to atRAL(cytosol)

Stable Identifier
R-HSA-2464810
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
atRAL diffuses through membranes to cytosol
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Summation

The majority of all-trans-retinal (atRAL) simply diffuses across membranes into the cytosol. Experiments performed with mice rods demonstrate that atRAL diffusion is independent of assisted transport by ABCA4 (Mata et al. 2000, Blakeley et al. 2011).

Literature References
PubMed ID Title Journal Year
21398289 Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation

Blakeley, LR, Chen, C, Chen, CK, Chen, J, Crouch, RK, Travis, GH, Koutalos, Y

Invest. Ophthalmol. Vis. Sci. 2011
10852960 Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

Mata, NL, Weng, J, Travis, GH

Proc. Natl. Acad. Sci. U.S.A. 2000
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