Phosphorylation of cohesin by PLK1 at chromosomal arms

Stable Identifier
R-HSA-2466068
Type
Reaction [transition]
Species
Homo sapiens
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Prior to anaphase onset, sister-chromatids are held together by cohesin complexes. PLK1-dependent phosphorylation of the cohesin subunit STAG2 (SA2) (Hauf et al. 2005) promotes dissociation of cohesins from chromosomal arms in prometaphase (Hauf et al. 2001). Besides phosphorylating STAG2, PLK1 also phosphorylates RAD21 cohesin subunit, but the phosphorylation of RAD21 is not required for the dissociation of cohesin from chromosomal arms in early mitosis (Hauf et al. 2005). There are several potential PLK1 phosphorylation sites in STAG2 and RAD21, but the exact positions of in vivo phosphorylation of STAG2 and RAD21 by PLK1 have not been explicitly established (Hauf et al. 2005). It is likely that the phosphorylation of cohesin-bound CDCA5 (Sororin) by CDK1 creates a docking site for PLK1 at threonine T159 of CDCA5, thus enabling PLK1 to phosphorylate cohesin subunits (Zhang et al. 2011).

Literature References
PubMed ID Title Journal Year
11509732 Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

Peters, JM, Hauf, S, Waizenegger, IC

Science 2001
21987589 Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion

Pati, D, Mao, Q, Panigrahi, AK, Zhang, N

J. Biol. Chem. 2011
15737063 Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2

Roitinger, E, Mechtler, K, Dittrich, CM, Peters, JM, Hauf, S, Koch, B

PLoS Biol 2005
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protein serine/threonine kinase activity of PLK1 [cytosol]

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