Reactome | NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter

NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter

Stable Identifier

R-HSA-2466367

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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General

SBML |

SVG | | PPTX | SBGN

NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter

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Both PRC (PPRC1) and NRF2 bind HCF1 (Vercauteren et al. 2008). PRC, like PGC-1alpha, can coactivate NRF2 (Gleyzer et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
18343819	PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression Vercauteren, K, Gleyzer, N, Scarpulla, RC	J Biol Chem	2008
15684387	Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators Gleyzer, N, Vercauteren, K, Scarpulla, RC	Mol Cell Biol	2005

Participants

Input

Output

TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Transcriptional activation of mitochondrial biogenesis

Authored

May, B (2011-08-20)

Reviewed

Lezza, AM (2013-12-07)

Created

May, B (2012-09-09)