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AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins)
Stable Identifier
R-HSA-2467436
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
Synonyms
Agrin binds Integrins alphaVbeta1 (Other beta1-containing integrins)
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
General
SBML
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BioPAX
Level 2
Level 3
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PDF
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PNG
Low
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High
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PPTX
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Agrin (AGRN) is a >400 kDa multi-domain heparan sulfate proteoglycan found in basement membranes. It is a critical organizer of postsynaptic differentiation at the skeletal neuromuscular junction; synaptogenesis is profoundly disrupted in its absence (Gautam et al. 1996). Two alternate N-termini exist. The predominant longer LN form (Burgess et al. 2000) starts with a secretion signal sequence and a laminin-binding domain (Denzer et al. 1995, Kammerer et al. 1999); the shorter SN form associates with the plasma membrane (Burgess et al. 2000, Neumann et al. 2001). Following the SN or LN regions are 8 follistatin repeats, known to bind growth factors and inhibit proteases in other proteins. The central region has two repeats homologous to domain III of laminin. The C-terminal portion, which is responsible for the molecule's known signaling functions, contains four EGF repeats and three LG (G) domains homologous to those found in laminin alpha chains, neurexins and slits (Timpl et al. 2000).
The LG domains bind alphaVbeta1 and another beta1-containing integrin (Martin & Sanes 1997, Burgess et al. 2002, Bezakova & Ruegg 2003). The N-terminus of the LN form of AGRN binds to the laminin gamma-1 subunit (Denzer et al. 1997, Kammerer et al. 1999). This may indirectly bind AGRN to integrins on the cell surface (Bezakova & Ruegg 2003).
Participants
Input
AGRN(30-2045) [extracellular region]
(Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane]
(Homo sapiens)
Output
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin cell surface interactions (Homo sapiens)
Inferred From
Agrin binds Integrin alphaVbeta1 (alpha1beta1) (Gallus gallus)
Authored
Jupe, S (2012-08-08)
Reviewed
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2012-09-12)
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