AGRN binds Beta amyloid fibril via GAG chains

Stable Identifier
R-HSA-2467665
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Several agrin (AGRN) ligands require the presence of heparan-sulfate GAG sidechains and probably represent interactions with them. Extracellular ligands include Beta-amyloid (Donahue et al. 1999, Cotman et al. 2000). Other ligands (unconfirmed in humans) include alpha-synuclein fibrils (chicken - Liu et al. 2005), HB-GAM/pleiotropin (Dagget et al. 1996), thrombospondin and FGF2 (Cotman et al. 1999).

Literature References
PubMed ID Title Journal Year
10673326 Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain

Cotman, SL, Halfter, W, Cole, GJ

Mol. Cell. Neurosci. 2000
10339611 Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma

Donahue, JE, Berzin, TM, Rafii, MS, Glass, DJ, Yancopoulos, GD, Fallon, JR, Stopa, EG

Proc. Natl. Acad. Sci. U.S.A. 1999
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