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A2E is phagocytosed
Stable Identifier
R-HSA-2467761
Type
Reaction [transition]
Species
Homo sapiens
Compartment
photoreceptor outer segment membrane
,
phagolysosome
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Diseases of the neuronal system (Homo sapiens)
Diseases associated with visual transduction (Homo sapiens)
Retinoid cycle disease events (Homo sapiens)
Biosynthesis of A2E, implicated in retinal degradation (Homo sapiens)
A2E is phagocytosed (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
Biosynthesis of A2E, implicated in retinal degradation (Homo sapiens)
A2E is phagocytosed (Homo sapiens)
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Early experiments in frog and other species determined that the outer segments of photoreceptors are renewed by phagocytosis and transfer to retinal pigment eplithelial (RPE) cells for processing. A2E, formed in disc membranes of outer segments, is taken along with the phagolysosome (Young 1967, Young & Bok 1969, Katz et al. 1986). Here, for simplicity, only A2E is shown in the phagolysosome.
Literature References
PubMed ID
Title
Journal
Year
3792460
Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium
Drea, CM
,
Eldred, GE
,
Hess, HH
,
Robison, WG
,
Katz, ML
Exp. Eye Res.
1986
6033942
The renewal of photoreceptor cell outer segments
Young, RW
J. Cell Biol.
1967
5792328
Participation of the retinal pigment epithelium in the rod outer segment renewal process
Young, RW
,
Bok, D
J. Cell Biol.
1969
Participants
Input
A2E [photoreceptor outer segment membrane]
Output
A2E [phagolysosome]
Participates
as an event of
Biosynthesis of A2E, implicated in retinal degradation (Homo sapiens)
Disease
Name
Identifier
Synonyms
dystrophies primarily involving the retinal pigment epithelium
DOID:14252
Authored
Jassal, B (2012-09-13)
Reviewed
Blaner, WS (2013-01-31)
Created
Jassal, B (2012-09-13)
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