Autocleavage of ESPL1 (Separase)

Stable Identifier
R-HSA-2467775
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Autocleavage of Separin
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After APC/C-mediated degradation of PTTG1 (securin), ESPL1 (separin i.e. separase) is rapidly autocatalytically cleaved after arginine residues at positions 1506 and 1535. The N-terminal and C-terminal fragments remain bound to each other after cleavage. It has not been examined what happens with the short middle fragment of ESPL1, so it is annotated as a part of the autocleaved ESPL1 complex. The autocatalytic cleavage of ESPL1 is not a prerequisite for the subsequent cleavage of the cohesin subunit RAD21 (Waizenegger et al. 2002).

Literature References
PubMed ID Title Journal Year
12194817 Regulation of human separase by securin binding and autocleavage

Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM

Curr. Biol. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type peptidase activity of ESPL1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created